Reference - Detail
| RRC ID | 33168 |
|---|---|
| Author | Okabe F, Nakagiri Y, Yamada T, Kose H. |
| Title | Laser induced injury caused hyperglycemia-like effect in Drosophila larva: a possible insect model for posttraumatic diabetes. |
| Journal | J Vet Med Sci |
| Abstract |
Diabetic patients need particular care in case of infection, digestive disorder or external injury, because external stress often exasperates the glucose metabolism, which is known as "sick day management". In addition, severe trauma can be a cause of hyperglycemia with insulin resistance. In spite of critical component of the treatment, the precise mechanisms of how trauma develops posttraumatic diabetes remain unknown. Here, we ablated body wall muscles in Drosophila larvae by laser beam and found that the level of trehalose, the principal sugar circulating in the hemolymph or in the tissues of most insects, was increased. The model may provide a helpful tool to understand the relationship between trauma and sugar metabolism. |
| Volume | 77(5) |
| Pages | 601-4 |
| Published | 2015-5-1 |
| DOI | 10.1292/jvms.14-0631 |
| PMID | 25649060 |
| PMC | PMC4478742 |
| MeSH | Animals Disease Models, Animal* Drosophila / metabolism* Drosophila / radiation effects* Glucose / metabolism* Larva / metabolism Larva / radiation effects Lasers* |
| IF | 1.049 |
| Times Cited | 1 |
| WOS Category | VETERINARY SCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Drosophila | 5053A-Gal4 (DGRC#107443) NP6310 (DGRC#113906) |