論文 - 詳細
| RRC ID | 33175 |
|---|---|
| 著者 | Palmer WH, Jia D, Deng WM. |
| タイトル | Cis-interactions between Notch and its ligands block ligand-independent Notch activity. |
| ジャーナル | Elife |
| Abstract |
The Notch pathway is integrated into numerous developmental processes and therefore is fine-tuned on many levels, including receptor production, endocytosis, and degradation. Notch is further characterized by a twofold relationship with its Delta-Serrate (DSL) ligands, as ligands from opposing cells (trans-ligands) activate Notch, whereas ligands expressed in the same cell (cis-ligands) inhibit signaling. We show that cells without both cis- and trans-ligands can mediate Notch-dependent developmental events during Drosophila oogenesis, indicating ligand-independent Notch activity occurs when the receptor is free of cis- and trans-ligands. Furthermore, cis-ligands can reduce Notch activity in endogenous and genetically induced situations of elevated trans-ligand-independent Notch signaling. We conclude that cis-expressed ligands exert their repressive effect on Notch signaling in cases of trans-ligand-independent activation, and propose a new function of cis-inhibition which buffers cells against accidental Notch activity. |
| 巻・号 | 3 |
| 公開日 | 2014-12-8 |
| DOI | 10.7554/eLife.04415 |
| PMID | 25486593 |
| PMC | PMC4286723 |
| MeSH | Animals Base Sequence DNA Primers Drosophila Ligands Oogenesis Protein Binding RNA Interference Receptors, Notch / genetics Receptors, Notch / metabolism* |
| IF | 7.08 |
| 引用数 | 27 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | tsg101[111019] |