RRC ID 33175
著者 Palmer WH, Jia D, Deng WM.
タイトル Cis-interactions between Notch and its ligands block ligand-independent Notch activity.
ジャーナル Elife
Abstract The Notch pathway is integrated into numerous developmental processes and therefore is fine-tuned on many levels, including receptor production, endocytosis, and degradation. Notch is further characterized by a twofold relationship with its Delta-Serrate (DSL) ligands, as ligands from opposing cells (trans-ligands) activate Notch, whereas ligands expressed in the same cell (cis-ligands) inhibit signaling. We show that cells without both cis- and trans-ligands can mediate Notch-dependent developmental events during Drosophila oogenesis, indicating ligand-independent Notch activity occurs when the receptor is free of cis- and trans-ligands. Furthermore, cis-ligands can reduce Notch activity in endogenous and genetically induced situations of elevated trans-ligand-independent Notch signaling. We conclude that cis-expressed ligands exert their repressive effect on Notch signaling in cases of trans-ligand-independent activation, and propose a new function of cis-inhibition which buffers cells against accidental Notch activity.
巻・号 3
公開日 2014-12-8
DOI 10.7554/eLife.04415
PMID 25486593
PMC PMC4286723
MeSH Animals Base Sequence DNA Primers Drosophila Ligands Oogenesis Protein Binding RNA Interference Receptors, Notch / genetics Receptors, Notch / metabolism*
IF 7.08
引用数 27
リソース情報
ショウジョウバエ tsg101[111019]