Reference - Detail
| RRC ID | 3328 |
|---|---|
| Author | Ogawa T, Murakami K, Mori H, Ishii N, Tomita M, Yoshin M. |
| Title | Role of phosphoenolpyruvate in the NADP-isocitrate dehydrogenase and isocitrate lyase reaction in Escherichia coli. |
| Journal | J Bacteriol |
| Abstract |
Phosphoenolpyruvate inhibited Escherichia coli NADP-isocitrate dehydrogenase allosterically (Ki of 0.31 mM) and isocitrate lyase uncompetitively (Ki' of 0.893 mM). Phosphoenolpyruvate enhances the uncompetitive inhibition of isocitrate lyase by increasing isocitrate, which protects isocitrate dehydrogenase from the inhibition, and contributes to the control through the tricarboxylic acid cycle and glyoxylate shunt. |
| Volume | 189(3) |
| Pages | 1176-8 |
| Published | 2007-2-1 |
| DOI | 10.1128/JB.01628-06 |
| PII | JB.01628-06 |
| PMID | 17142397 |
| PMC | PMC1797289 |
| MeSH | Escherichia coli / drug effects Escherichia coli / enzymology Escherichia coli / metabolism* Isocitrate Dehydrogenase / antagonists & inhibitors Isocitrate Dehydrogenase / metabolism* Isocitrate Lyase / antagonists & inhibitors Isocitrate Lyase / metabolism* Isocitrates / metabolism Isocitrates / pharmacology Kinetics NADP / metabolism Phosphoenolpyruvate / metabolism* Phosphoenolpyruvate / pharmacology |
| IF | 3.006 |
| Times Cited | 13 |
| WOS Category | MICROBIOLOGY |
| Resource | |
| Prokaryotes E. coli | ? W3110 |