RRC ID 33329
Author Zhang S, Chen C, Wu C, Yang Y, Li W, Xue L.
Title The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila.
Journal Cell Death Dis
Abstract Cell death is an essential regulatory mechanism for removing unneeded cells in animal development and tissue homeostasis. The c-Jun N-terminal kinase (JNK) pathway has pivotal roles in the regulation of cell death in response to various intrinsic and extrinsic stress signals. The canonical Wingless (Wg) signaling has been implicated in cell proliferation and cell fate decisions, whereas its role in cell death remains largely elusive. Here, we report that activated Bsk (the Drosophila JNK homolog) induced cell death is mediated by the canonical Wg signaling. First, loss of Wg signaling abrogates Bsk-mediated caspase-independent cell death. Second, activation of Wg signaling promotes cell death in a caspase-independent manner. Third, activation of Bsk signaling results in upregulated transcription of wingless (wg) gene. Finally, Wg pathway participates in the physiological function of Bsk signaling in development. These findings not only reveal a previously undiscovered role of Wg signaling in Bsk-mediated cell death, but also provide a novel mechanism for the interplay between the two important signaling pathways in development.
Volume 6
Pages e1713
Published 2015-4-9
DOI 10.1038/cddis.2015.85
PII cddis201585
PMID 25855961
PMC PMC4650552
MeSH Animals Cell Death / genetics Drosophila / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Signal Transduction Transcription Factors / metabolism Wnt1 Protein / genetics Wnt1 Protein / metabolism*
IF 5.638
Times Cited 5
Drosophila 4889R-3 4889R-4 11579R-1 11579R-2 8091R-1 8091R-2 7788R-1 7788R-2 5370R-2