論文 - 詳細
| RRC ID | 33329 |
|---|---|
| 著者 | Zhang S, Chen C, Wu C, Yang Y, Li W, Xue L. |
| タイトル | The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila. |
| ジャーナル | Cell Death Dis |
| Abstract |
Cell death is an essential regulatory mechanism for removing unneeded cells in animal development and tissue homeostasis. The c-Jun N-terminal kinase (JNK) pathway has pivotal roles in the regulation of cell death in response to various intrinsic and extrinsic stress signals. The canonical Wingless (Wg) signaling has been implicated in cell proliferation and cell fate decisions, whereas its role in cell death remains largely elusive. Here, we report that activated Bsk (the Drosophila JNK homolog) induced cell death is mediated by the canonical Wg signaling. First, loss of Wg signaling abrogates Bsk-mediated caspase-independent cell death. Second, activation of Wg signaling promotes cell death in a caspase-independent manner. Third, activation of Bsk signaling results in upregulated transcription of wingless (wg) gene. Finally, Wg pathway participates in the physiological function of Bsk signaling in development. These findings not only reveal a previously undiscovered role of Wg signaling in Bsk-mediated cell death, but also provide a novel mechanism for the interplay between the two important signaling pathways in development. |
| 巻・号 | 6(4) |
| ページ | e1713 |
| 公開日 | 2015-4-9 |
| DOI | 10.1038/cddis.2015.85 |
| PII | cddis201585 |
| PMID | 25855961 |
| PMC | PMC4650552 |
| MeSH | Animals Cell Death / genetics Drosophila / metabolism* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Signal Transduction Transcription Factors / metabolism Wnt1 Protein / genetics Wnt1 Protein / metabolism* |
| IF | 6.304 |
| 引用数 | 9 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 4889R-3 4889R-4 11579R-1 11579R-2 8091R-1 8091R-2 7788R-1 7788R-2 5370R-2 |