論文 - 詳細
| RRC ID | 33587 |
|---|---|
| 著者 | Nihashi J, Fujita Y. |
| タイトル | Catabolite repression of inositol dehydrogenase and gluconate kinase syntheses in Bacillus subtilis. |
| ジャーナル | Biochim Biophys Acta |
| Abstract |
The regulation of induction of inositol dehydrogenase (EC 1.1.1.18) and gluconate kinase (EC 2.7.1.12) was studied in Bacillus subtilis. Inositol dehydrogenase is induced by myo-inositol and gluconate kinase is induced by D-gluconate. Both inductions were strongly repressed by rapidly metabolizable carbohydrates such as D-glucose, D-mannose, D-fructose and glycerol (D-glucose had the strongest repressive effect) but they were weakly repressed by slowly metabolizable carbohydrates. Although each carbohydrate exerted a stronger effect on the induction of inositol dehydrogenase than that of gluconate kinase, it showed a similar tendency with respect to the degree of repression of each induction. This catabolite repression could not be diminished by addition of cyclic AMP to medium. In addition, non-metabolizable D-glucose analogues had no or weak repressive effects. On the assumption that rapidly metabolizable carbohydrates might be metabolized to repress both inductions, it was investigated whether several mutants blocked in the Embden-Meyerhof pathway could produce metabolite(s) (repressor) to repress them. A phosphoglycerate kinase (EC 2.7.2.3) deficient mutant could produce the repressor from D-glucose, D-mannose, D-fructose and glycerol but other mutants could not produce it from carbohydrates unable to be metabolized in each mutant. Thus, catabolite repression of both enzyme inductions seemed to be under similar regulation. The identification of the possible repressor of the induction of in of inositol dehydrogenase and gluconate kinase in vivo was discussed. |
| 巻・号 | 798(1) |
| ページ | 88-95 |
| 公開日 | 1984-3-22 |
| DOI | 10.1016/0304-4165(84)90014-x |
| PII | 0304-4165(84)90014-X |
| PMID | 6322857 |
| MeSH | Bacillus subtilis / enzymology* Carbohydrates / pharmacology Enzyme Induction Enzyme Repression Genotype Phosphotransferases / biosynthesis* Phosphotransferases (Alcohol Group Acceptor)* Species Specificity Sugar Alcohol Dehydrogenases / biosynthesis* |
| IF | 3.411 |
| 引用数 | 50 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(枯草菌) | MBS69 MBS70 MBS71 MBS72 MBS73 MBS74 |