Reference - Detail
| RRC ID | 33650 |
|---|---|
| Author | Pauli A, Norris ML, Valen E, Chew GL, Gagnon JA, Zimmerman S, Mitchell A, Ma J, Dubrulle J, Reyon D, Tsai SQ, Joung JK, Saghatelian A, Schier AF. |
| Title | Toddler: an embryonic signal that promotes cell movement via Apelin receptors. |
| Journal | Science |
| Abstract |
It has been assumed that most, if not all, signals regulating early development have been identified. Contrary to this expectation, we identified 28 candidate signaling proteins expressed during zebrafish embryogenesis, including Toddler, a short, conserved, and secreted peptide. Both absence and overproduction of Toddler reduce the movement of mesendodermal cells during zebrafish gastrulation. Local and ubiquitous production of Toddler promote cell movement, suggesting that Toddler is neither an attractant nor a repellent but acts globally as a motogen. Toddler drives internalization of G protein-coupled APJ/Apelin receptors, and activation of APJ/Apelin signaling rescues toddler mutants. These results indicate that Toddler is an activator of APJ/Apelin receptor signaling, promotes gastrulation movements, and might be the first in a series of uncharacterized developmental signals. |
| Volume | 343(6172) |
| Pages | 1248636 |
| Published | 2014-2-14 |
| DOI | 10.1126/science.1248636 |
| PII | science.1248636 |
| PMID | 24407481 |
| PMC | PMC4107353 |
| MeSH | Amino Acid Sequence Animals Apelin Receptors Cell Movement* Chemokine CXCL12 / metabolism Frameshift Mutation Gastrulation / genetics Gastrulation / physiology* Molecular Sequence Data Receptors, G-Protein-Coupled / genetics Receptors, G-Protein-Coupled / metabolism* Signal Transduction Zebrafish / embryology* Zebrafish / genetics Zebrafish / metabolism Zebrafish Proteins / genetics Zebrafish Proteins / metabolism* |
| IF | 41.846 |
| Times Cited | 256 |
| WOS Category | CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 65 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Zebrafish | Tg(sox17:EGFP)/ha01 |