論文 - 詳細
| RRC ID | 33665 |
|---|---|
| 著者 | Xiong F, Tentner AR, Huang P, Gelas A, Mosaliganti KR, Souhait L, Rannou N, Swinburne IA, Obholzer ND, Cowgill PD, Schier AF, Megason SG. |
| タイトル | Specified neural progenitors sort to form sharp domains after noisy Shh signaling. |
| ジャーナル | Cell |
| Abstract |
Sharply delineated domains of cell types arise in developing tissues under instruction of inductive signal (morphogen) gradients, which specify distinct cell fates at different signal levels. The translation of a morphogen gradient into discrete spatial domains relies on precise signal responses at stable cell positions. However, cells in developing tissues undergoing morphogenesis and proliferation often experience complex movements, which may affect their morphogen exposure, specification, and positioning. How is a clear pattern achieved with cells moving around? Using in toto imaging of the zebrafish neural tube, we analyzed specification patterns and movement trajectories of neural progenitors. We found that specified progenitors of different fates are spatially mixed following heterogeneous Sonic Hedgehog signaling responses. Cell sorting then rearranges them into sharply bordered domains. Ectopically induced motor neuron progenitors also robustly sort to correct locations. Our results reveal that cell sorting acts to correct imprecision of spatial patterning by noisy inductive signals. |
| 巻・号 | 153(3) |
| ページ | 550-61 |
| 公開日 | 2013-4-25 |
| DOI | 10.1016/j.cell.2013.03.023 |
| PII | S0092-8674(13)00345-0 |
| PMID | 23622240 |
| PMC | PMC3674856 |
| MeSH | Animals Cell Movement Embryo, Nonmammalian / cytology Embryo, Nonmammalian / metabolism Hedgehog Proteins / metabolism Morphogenesis* Neural Stem Cells / metabolism* Neural Tube / cytology* Signal Transduction* Zebrafish / embryology* Zebrafish / metabolism Zebrafish Proteins / metabolism |
| IF | 38.637 |
| 引用数 | 86 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Blogs |
| 各媒体での言及数の合計 | 31 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(HuC:Kaede)/rw0130a |