論文 - 詳細
| RRC ID | 33686 |
|---|---|
| 著者 | Randlett O, MacDonald RB, Yoshimatsu T, Almeida AD, Suzuki SC, Wong RO, Harris WA. |
| タイトル | Cellular requirements for building a retinal neuropil. |
| ジャーナル | Cell Rep |
| Abstract |
How synaptic neuropil is formed within the CNS is poorly understood. The retinal inner plexiform layer (IPL) is positioned between the cell bodies of amacrine cells (ACs) and retinal ganglion cells (RGCs). It consists of bipolar cell (BC) axon terminals that synapse on the dendrites of ACs and RGCs intermingled with projections from Müller glia (MG). We examined whether any of these cellular processes are specifically required for the formation of the IPL. Using genetic and pharmacological strategies, we eliminated RGCs, ACs, and MG individually or in combination. Even in the absence of all of these partner cells, an IPL-like neuropil consisting of only BC axon terminals still forms, complete with presynaptic specializations and sublaminar organization. Previous studies have shown that an IPL can form in the complete absence of BCs; therefore, we conclude that neither presynaptic nor postsynaptic processes are individually essential for the formation of this synaptic neuropil. |
| 巻・号 | 3(2) |
| ページ | 282-90 |
| 公開日 | 2013-2-21 |
| DOI | 10.1016/j.celrep.2013.01.020 |
| PII | S2211-1247(13)00027-2 |
| PMID | 23416047 |
| PMC | PMC3607253 |
| MeSH | Amacrine Cells / cytology Amacrine Cells / pathology Amacrine Cells / ultrastructure Animals Animals, Genetically Modified Embryo, Nonmammalian / metabolism Microscopy, Fluorescence Microscopy, Video Neurons / pathology Neuropil / cytology* Neuropil / pathology Presynaptic Terminals / pathology Retina / pathology Retina / ultrastructure* Retinal Bipolar Cells / cytology Retinal Bipolar Cells / pathology Retinal Bipolar Cells / ultrastructure Retinal Ganglion Cells / cytology Retinal Ganglion Cells / pathology Retinal Ganglion Cells / ultrastructure Synapses / pathology Synapses / ultrastructure Zebrafish / growth & development |
| IF | 8.109 |
| 引用数 | 23 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(vsx1:GFP) |