Reference - Detail
| RRC ID | 33713 |
|---|---|
| Author | Ma X, Xu W, Zhang D, Yang Y, Li W, Xue L. |
| Title | Wallenda regulates JNK-mediated cell death in Drosophila. |
| Journal | Cell Death Dis |
| Abstract |
The c-Jun N-terminal kinase (JNK) pathway plays essential roles in regulating a variety of cellular processes including proliferation, migration and survival. Previous genetic studies in Drosophila have identified numerous cell death regulating genes, providing new insights into the mechanisms for related diseases. Despite the known role of the small GTPase Rac1 in regulating cell death, the downstream components and underlying mechanism remain largely elusive. Here, we show that Rac1 promotes JNK-dependent cell death through Wallenda (Wnd). In addition, we find that Wnd triggers JNK activation and cell death via its kinase domain. Moreover, we show that both MKK4 and Hep are critical for Wnd-induced cell death. Furthermore, Wnd is essential for ectopic Egr- or Rho1-induced JNK activation and cell death. Finally, Wnd is physiologically required for loss of scribble-induced JNK-dependent cell death. Thus, our data suggest that wnd encodes a novel essential cell death regulator in Drosophila. |
| Volume | 6(5) |
| Pages | e1737 |
| Published | 2015-5-7 |
| DOI | 10.1038/cddis.2015.111 |
| PII | cddis2015111 |
| PMID | 25950467 |
| PMC | PMC4669691 |
| MeSH | Animals Apoptosis / physiology Cell Death / physiology Drosophila Drosophila Proteins / genetics* Drosophila Proteins / metabolism JNK Mitogen-Activated Protein Kinases / metabolism* MAP Kinase Kinase Kinases / genetics* MAP Kinase Kinase Kinases / metabolism |
| IF | 6.304 |
| Times Cited | 13 |
| WOS Category | CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | News |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 2248R-1 |