論文 - 詳細
| RRC ID | 33720 |
|---|---|
| 著者 | Bartok O, Teesalu M, Ashwall-Fluss R, Pandey V, Hanan M, Rovenko BM, Poukkula M, Havula E, Moussaieff A, Vodala S, Nahmias Y, Kadener S, Hietakangas V. |
| タイトル | The transcription factor Cabut coordinates energy metabolism and the circadian clock in response to sugar sensing. |
| ジャーナル | EMBO J |
| Abstract |
Nutrient sensing pathways adjust metabolism and physiological functions in response to food intake. For example, sugar feeding promotes lipogenesis by activating glycolytic and lipogenic genes through the Mondo/ChREBP-Mlx transcription factor complex. Concomitantly, other metabolic routes are inhibited, but the mechanisms of transcriptional repression upon sugar sensing have remained elusive. Here, we characterize cabut (cbt), a transcription factor responsible for the repressive branch of the sugar sensing transcriptional network in Drosophila. We demonstrate that cbt is rapidly induced upon sugar feeding through direct regulation by Mondo-Mlx. We found that CBT represses several metabolic targets in response to sugar feeding, including both isoforms of phosphoenolpyruvate carboxykinase (pepck). Deregulation of pepck1 (CG17725) in mlx mutants underlies imbalance of glycerol and glucose metabolism as well as developmental lethality. Furthermore, we demonstrate that cbt provides a regulatory link between nutrient sensing and the circadian clock. Specifically, we show that a subset of genes regulated by the circadian clock are also targets of CBT. Moreover, perturbation of CBT levels leads to deregulation of the circadian transcriptome and circadian behavioral patterns. |
| 巻・号 | 34(11) |
| ページ | 1538-53 |
| 公開日 | 2015-6-3 |
| DOI | 10.15252/embj.201591385 |
| PII | embj.201591385 |
| PMID | 25916830 |
| PMC | PMC4474529 |
| MeSH | Animals Circadian Clocks / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster Energy Metabolism / physiology* Feeding Behavior / physiology* Glucose / genetics Glucose / metabolism* Glycerol / metabolism Phosphoenolpyruvate Carboxykinase (ATP) / genetics Phosphoenolpyruvate Carboxykinase (ATP) / metabolism Transcription Factors / genetics Transcription Factors / metabolism* Transcriptome / physiology* |
| IF | 9.889 |
| 引用数 | 22 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 22 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 4427R-1 |