Reference - Detail
| RRC ID | 34253 |
|---|---|
| Author | Chohnan S, Murase M, Kurikawa K, Higashi K, Ogata Y. |
| Title | Antimicrobial activity of pantothenol against staphylococci possessing a prokaryotic type II pantothenate kinase. |
| Journal | Microbes Environ |
| Abstract |
Pantothenol is a provitamin of pantothenic acid (vitamin B5) that is widely used in healthcare and cosmetic products. This analog of pantothenate has been shown to markedly inhibit the phosphorylation activity of the prokaryotic type II pantothenate kinase of Staphylococcus aureus, which catalyzes the first step of the coenzyme A biosynthetic pathway. Since type II enzymes are found exclusively in staphylococci, pantothenol suppresses the growth of S. aureus, S. epidermidis, and S. saprophyticus, which inhabit the skin of humans. Therefore, the addition of this provitamin to ointment and skincare products may be highly effective in preventing infections by opportunistic pathogens. |
| Volume | 29(2) |
| Pages | 224-6 |
| Published | 2014-1-1 |
| DOI | 10.1264/jsme2.me13178 |
| PII | DN/JST.JSTAGE/jsme2/ME13178 |
| PMID | 24759689 |
| PMC | PMC4103530 |
| MeSH | Amino Acid Sequence Anti-Infective Agents / pharmacology* Bacterial Proteins / antagonists & inhibitors Biosynthetic Pathways / drug effects Coenzyme A / biosynthesis Escherichia coli K12 / drug effects Escherichia coli K12 / enzymology Escherichia coli K12 / growth & development Humans Microbial Sensitivity Tests Pantothenic Acid / analogs & derivatives* Pantothenic Acid / chemistry Pantothenic Acid / pharmacology Phosphorylation / drug effects Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors* Pseudomonas putida / drug effects Pseudomonas putida / enzymology Pseudomonas putida / growth & development Staphylococcal Infections / drug therapy* Staphylococcal Infections / microbiology Staphylococcus / drug effects* Staphylococcus / enzymology Staphylococcus / growth & development |
| IF | 2.575 |
| Times Cited | 1 |
| WOS Category | BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY |
| Resource | |
| General Microbes | JCM 20089 |