論文 - 詳細
| RRC ID | 34258 |
|---|---|
| 著者 | Fujii T, Shinozaki J, Kajiura T, Iwasaki K, Fudou R. |
| タイトル | A newly discovered Anaerococcus strain responsible for axillary odor and a new axillary odor inhibitor, pentagalloyl glucose. |
| ジャーナル | FEMS Microbiol Ecol |
| Abstract |
Skin surface bacteria contribute to body odor, especially axillary odor. We aimed to investigate anaerobic bacteria that had not been previously studied for axillary odor formation. A new anaerobic Anaerococcus sp. A20, that releases 3-hydroxy-3-metyl-hexanoic acid (HMHA, main component of axillary odor) from its glutamyl conjugate, was discovered from axillary isolates. This strain showed strong resistance to the antimicrobial agents, triclosan and 4-isopropyl-3-methylphenol; therefore, we screened plant extracts that inhibit the A20 strain. We discovered that pentagalloyl glucose (PGG) extracted from the Chinese Gall plant exhibited both antibacterial and inhibitory activities against HMHA release by the A20 strain. As the excellent antibacterial activity and inhibitory effect of PGG against HMHA release were seen in vitro, we conducted an open study to evaluate the deodorant effects of PGG on axillary odor. The sensory tests on odor strength showed that application of the PGG solution could reduce axillary odors in vivo. Although there was a small change in axillary microbiota, the microbial count of A20 significantly reduced. These results strongly indicate PGG as a new innovative deodorant material that only affects odor-releasing bacteria in the axillary microbiota. |
| 巻・号 | 89(1) |
| ページ | 198-207 |
| 公開日 | 2014-7-1 |
| DOI | 10.1111/1574-6941.12347 |
| PMID | 24784923 |
| MeSH | Anti-Bacterial Agents / pharmacology* Axilla / microbiology* Caproates / metabolism Cresols / pharmacology Drug Resistance, Bacterial Female Genes, Bacterial Gram-Positive Bacteria / drug effects* Gram-Positive Bacteria / genetics Gram-Positive Bacteria / isolation & purification Gram-Positive Bacteria / metabolism Humans Hydrolyzable Tannins / pharmacology* Male Microbial Sensitivity Tests Molecular Typing Odorants Phylogeny RNA, Ribosomal, 16S / genetics Skin / microbiology* Sweat / microbiology Triclosan / pharmacology |
| IF | 3.675 |
| 引用数 | 6 |
| WOS 分野 | MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1964 JCM 6425 JCM 6508 JCM 7635 JCM 8140 JCM 8138 JCM 15630 |