論文 - 詳細
| RRC ID | 34277 |
|---|---|
| 著者 | Egan M, O'Connell Motherway M, Ventura M, van Sinderen D. |
| タイトル | Metabolism of sialic acid by Bifidobacterium breve UCC2003. |
| ジャーナル | Appl Environ Microbiol |
| Abstract |
Bifidobacteria constitute a specific group of commensal bacteria that inhabit the gastrointestinal tracts of humans and other mammals. Bifidobacterium breve UCC2003 has previously been shown to utilize several plant-derived carbohydrates that include cellodextrins, starch, and galactan. In the present study, we investigated the ability of this strain to utilize the mucin- and human milk oligosaccharide (HMO)-derived carbohydrate sialic acid. Using a combination of transcriptomic and functional genomic approaches, we identified a gene cluster dedicated to the uptake and metabolism of sialic acid. Furthermore, we demonstrate that B. breve UCC2003 can cross feed on sialic acid derived from the metabolism of 3'-sialyllactose, an abundant HMO, by another infant gut bifidobacterial strain, Bifidobacterium bifidum PRL2010. |
| 巻・号 | 80(14) |
| ページ | 4414-26 |
| 公開日 | 2014-7-1 |
| DOI | 10.1128/AEM.01114-14 |
| PII | AEM.01114-14 |
| PMID | 24814790 |
| PMC | PMC4068672 |
| MeSH | Bifidobacterium / genetics Bifidobacterium / metabolism* Culture Media DNA Fragmentation DNA, Bacterial / genetics Multigene Family N-Acetylneuraminic Acid / metabolism* Oligonucleotide Array Sequence Analysis Plasmids / genetics Sequence Analysis, DNA |
| IF | 4.016 |
| 引用数 | 69 |
| WOS 分野 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 7017 JCM 7019 |