論文 - 詳細
| RRC ID | 3435 |
|---|---|
| 著者 | Hu J, Bae YK, Knobel KM, Barr MM. |
| タイトル | Casein kinase II and calcineurin modulate TRPP function and ciliary localization. |
| ジャーナル | Mol Biol Cell |
| Abstract |
Cilia serve as sensory devices in a diversity of organisms and their defects contribute to many human diseases. In primary cilia of kidney cells, the transient receptor potential polycystin (TRPP) channels polycystin-1 (PC-1) and polycystin-2 (PC-2) act as a mechanosensitive channel, with defects resulting in autosomal dominant polycystic kidney disease. In sensory cilia of Caenorhabditis elegans male-specific neurons, the TRPPs LOV-1 and PKD-2 are required for mating behavior. The mechanisms regulating TRPP ciliary localization and function are largely unknown. We identified the regulatory subunit of the serine-threonine casein kinase II (CK2) as a binding partner of LOV-1 and human PC-1. CK2 and the calcineurin phosphatase TAX-6 modulate male mating behavior and PKD-2 ciliary localization. The phospho-defective mutant PKD-2(S534A) localizes to cilia, whereas a phospho-mimetic PKD-2(S534D) mutant is largely absent from cilia. Calcineurin is required for PKD-2 ciliary localization, but is not essential for ciliary gene expression, ciliogenesis, or localization of cilium structural components. This unanticipated function of calcineurin may be important for regulating ciliary protein localization. A dynamic phosphorylation-dephosphorylation cycle may represent a mechanism for modulating TRPP activity, cellular sensation, and ciliary protein localization. |
| 巻・号 | 17(5) |
| ページ | 2200-11 |
| 公開日 | 2006-5-1 |
| DOI | 10.1091/mbc.e05-10-0935 |
| PII | E05-10-0935 |
| PMID | 16481400 |
| PMC | PMC1446073 |
| MeSH | Amino Acid Sequence Animals Caenorhabditis elegans / anatomy & histology Caenorhabditis elegans / chemistry Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / analysis Caenorhabditis elegans Proteins / metabolism* Calcineurin / metabolism* Casein Kinase II / metabolism* Cilia / chemistry Cilia / metabolism Humans Male Molecular Sequence Data Phosphoric Monoester Hydrolases / metabolism Protein Interaction Mapping Sexual Behavior, Animal TRPP Cation Channels / analysis TRPP Cation Channels / metabolism* |
| IF | 3.791 |
| 引用数 | 44 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1283 |