Reference - Detail
| RRC ID | 34352 |
|---|---|
| Author | Kulakovskaya E, Baskunov B, Zvonarev A. |
| Title | The antibiotic and membrane-damaging activities of cellobiose lipids and sophorose lipids. |
| Journal | J Oleo Sci |
| Abstract |
Antibiotic activity was compared for Cryptococcus humicola cellobiose lipids, the mixture of 2,3,4-О-triacetyl-β-D-glucopyranosyl-(1→4)-(6-О-acetyl-β-D-glucopyranosyl-(1→16)-2,16-dihydroxyhexodecanoic acid and 2,3,4-О-triacetyl-β-D-glucopyranosyl-(1→4)-(6-О-acetyl-β-D-glucopyranosyl-(1→16)-2,17,18-trihydroxyoctotodecanoic acid, and the commercial sophorose lipid mixture of a mono-acetylated acidic sophorose lipid and a di-acetylated acidic sophorose lipid, both containing the C18:1 fatty acid residue. The MIC values of cellobiose lipids were 0.005 and 0.04 mg/mL for Filobasidiella neoformans and Candida tropicalis, respectively. The MIC values of sophorose lipids were 1 and 15 mg/mL for F. neoformans and C. tropicalis, respectively. MIC values for some bacteria were in the range of 10-30 mg/mL for both glycolipid preparations. Both sophorose lipids and cellobiose lipids displayed a membrane-damaging activity against F. neoformans. The treatment with these glycolipids reduces the content of ATP in the cells of test cultures and results in their staining with ethidium bromide. |
| Volume | 63(7) |
| Pages | 701-7 |
| Published | 2014-1-1 |
| DOI | 10.5650/jos.ess14037 |
| PII | DN/JST.JSTAGE/jos/ess14037 |
| PMID | 24976613 |
| MeSH | Adenosine Triphosphate / metabolism Anti-Bacterial Agents* Antifungal Agents* Candida tropicalis / cytology Candida tropicalis / drug effects* Candida tropicalis / metabolism Cell Membrane / drug effects* Cellobiose / chemistry Cellobiose / pharmacology* Cryptococcus neoformans / cytology Cryptococcus neoformans / drug effects* Cryptococcus neoformans / metabolism Dose-Response Relationship, Drug Drug Combinations Drug Resistance, Bacterial Drug Resistance, Fungal Glucans / chemistry Glucans / pharmacology* Lipids / chemistry Lipids / pharmacology* |
| IF | 1.304 |
| Times Cited | 7 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM 1542 |