| RRC ID |
34466
|
| Author |
Kasakura K, Takahashi K, Itoh T, Hosono A, Momose Y, Itoh K, Nishiyama C, Kaminogawa S.
|
| Title |
Commensal bacteria directly suppress in vitro degranulation of mast cells in a MyD88-independent manner.
|
| Journal |
Biosci Biotechnol Biochem
|
| Abstract |
The intestine harbors a substantial number of commensal bacteria that provide considerable benefits to the host. Epidemiologic studies have identified associations between alterations in the composition of the intestinal microbiota and the development of allergic disease. However, the cellular and molecular mechanisms underlying these effects remain to be determined. Here, we show that heat-killed commensal bacteria suppressed degranulation of mast cells in vitro in a MyD88-independent manner. In particular, Enterococcus faecalis showed the strongest suppression of degranulation through partial inhibition of Ca(2+) signaling upon the high affinity IgE receptor (FcεRI) cross-linking.
|
| Volume |
78(10)
|
| Pages |
1669-76
|
| Published |
2014-1-1
|
| DOI |
10.1080/09168451.2014.930327
|
| PMID |
25273132
|
| MeSH |
Animals
Cell Degranulation*
Enterococcus faecalis / physiology*
Female
Intracellular Space / metabolism
Mast Cells / cytology*
Mice
Myeloid Differentiation Factor 88 / metabolism*
Signal Transduction
|
| IF |
1.516
|
| Times Cited |
11
|
|
WOS Category
|
FOOD SCIENCE & TECHNOLOGY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
CHEMISTRY, APPLIED
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| General Microbes |
JCM 1649
JCM 5824
JCM 5826
JCM 5827 |
