Reference - Detail
| RRC ID | 34488 |
|---|---|
| Author | Kasakura K, Takahashi K, Itoh T, Hosono A, Nunomura S, Ra C, Momose Y, Itoh K, Nishiyama C, Kaminogawa S. |
| Title | C/EBPα controls mast cell function. |
| Journal | FEBS Lett |
| Abstract |
CCAAT/enhancer binding protein alpha (C/EBPα) is a transcription factor that influences immune cell fate and differentiation. However, the effect of C/EBPα on mast cells is not fully understood. In this study, we showed that C/EBPα suppressed granule formation in mast cells and increased macrophage inflammatory protein (MIP)-2 production from mast cells upon bacterial stimulation. These results indicate that C/EBPα regulates the balance between the allergic response and the innate immune response of mast cells. Furthermore, we showed that stimulation of mast cells with the Lactobacillus casei JCM1134(T) strain during late differentiation up-regulated C/EBPα expression in differentiated mast cells. This suggests that intestinal commensal bacteria modulate C/EBPα expression and thereby regulate mast cell function. |
| Volume | 588(24) |
| Pages | 4645-53 |
| Published | 2014-12-20 |
| DOI | 10.1016/j.febslet.2014.10.036 |
| PII | S0014-5793(14)00785-6 |
| PMID | 25447519 |
| MeSH | Animals Bone Marrow Cells / cytology CCAAT-Enhancer-Binding Protein-alpha / genetics CCAAT-Enhancer-Binding Protein-alpha / metabolism* Cell Differentiation Chemokine CXCL2 / biosynthesis Female Gene Expression Regulation Lacticaseibacillus casei / physiology Mast Cells / cytology* Mast Cells / immunology Mast Cells / metabolism* Mast Cells / microbiology Mice |
| IF | 3.057 |
| Times Cited | 7 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| General Microbes | JCM 1134 |