論文 - 詳細
| RRC ID | 3451 |
|---|---|
| 著者 | Fujiwara Y, Tanaka Y, Iwata K, Rubio RO, Yaginuma T, Yamashita O, Shiomi K. |
| タイトル | ERK/MAPK regulates ecdysteroid and sorbitol metabolism for embryonic diapause termination in the silkworm, Bombyx mori. |
| ジャーナル | J Insect Physiol |
| Abstract |
The eggs of the silkworm Bombyx mori undergo a state of suspended overt development and diminished metabolism called "diapause" to escape adverse environmental conditions. Termination of Bombyx embryonic diapause requires 2-3 months of low temperature (5 degrees C), but the molecular mechanisms underlying diapause termination are unknown. Diapause termination requires a decrease in the sorbitol concentration, which arrests embryonic development, and the secretion factors from yolk cells that promote embryonic development. In the present study, we report that 20-hydroxyecdysone promoted the development of denuded embryos and that ecdysteroid-phosphate phosphatase (EPPase), which is a key enzyme for active ecdysteroid production, was induced by incubation of diapausing eggs at 5 degrees C. In dechorionated egg cultures, extracellular signal-regulated kinase (ERK), which is activated by incubating diapausing eggs at 5 degrees C, regulated sorbitol-glycogen conversion, ecdysteroid secretion via gene transcription of key enzymes, sorbitol dehydrogenase-2, and EPPase, suggesting that ERK has a key role in diapause termination. |
| 巻・号 | 52(6) |
| ページ | 569-75 |
| 公開日 | 2006-6-1 |
| DOI | 10.1016/j.jinsphys.2006.02.004 |
| PII | S0022-1910(06)00031-X |
| PMID | 16546206 |
| MeSH | Animals Bombyx / embryology* Bombyx / metabolism Bombyx / physiology Cold Temperature Ecdysteroids / metabolism* Ecdysteroids / physiology Ecdysterone / physiology Egg Yolk / physiology Embryonic Development / physiology* Extracellular Signal-Regulated MAP Kinases / physiology* Female Gene Expression Glycogen / biosynthesis Phosphoric Monoester Hydrolases / metabolism Sorbitol / metabolism* |
| IF | 2.246 |
| 引用数 | 33 |
| WOS 分野 | ENTOMOLOGY ZOOLOGY PHYSIOLOGY |
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| 各媒体での言及数の合計 | 0 |
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