論文 - 詳細
| RRC ID | 34550 |
|---|---|
| 著者 | Kawabata K, Sugiyama Y, Sakano T, Ohigashi H. |
| タイトル | Flavonols enhanced production of anti-inflammatory substance(s) by Bifidobacterium adolescentis: prebiotic actions of galangin, quercetin, and fisetin. |
| ジャーナル | Biofactors |
| Abstract |
The gut microbiota is capable of the bioconversion of flavonoids whereas influences of probiotic anaerobes on the bioactivities of flavonoids and vice versa are still unclear. Here, we investigated functional interactions with respect to the anti-inflammatory activity between flavonols and probiotic bacteria. Ten enteric (6 probiotic and 4 indigenous) bacteria were incubated with flavonols (galangin, kaempferol, quercetin, myricetin, and fisetin) under anaerobic conditions, and the supernatants were assessed for their effects on nitric oxide (NO) production in lipopolysaccaride-stimulated RAW264 cells. Although the conditioned medium from the flavonol mono-culture and almost all of the tested co-cultures failed to inhibit NO production, the medium from the Bifidobacterium adolescentis/flavonols (galangin, quercetin, and fisetin) co-culture highly suppressed NO production. This activity increased during the 1-6 H incubation in a time-dependent manner and was not observed in the co-culture using heat-inactivated B. adolescentis. Interestingly, when the B. adolescentis cell number was increased, the supernatant from the mono-culture of the bacteria showed NO suppression, suggesting that B. adolescentis may produce NO suppressant(s), and flavonols may have a promoting effect. These findings indicate that flavonols have a prebiotic-like effect on the anti-inflammatory activity of B. adolescentis. |
| 巻・号 | 39(4) |
| ページ | 422-9 |
| 公開日 | 2013-1-1 |
| DOI | 10.1002/biof.1081 |
| PMID | 23554103 |
| MeSH | Animals Bacteroides / metabolism Bifidobacterium / drug effects Bifidobacterium / growth & development Bifidobacterium / metabolism* Cell Line Culture Media, Conditioned Flavonoids / pharmacology* Flavonols Hydroxybenzoates / pharmacology Lactobacillus / metabolism Lipopolysaccharides / pharmacology Megasphaera / metabolism Mice Nitric Oxide / metabolism Prebiotics* Probiotics / metabolism Quercetin / pharmacology* |
| IF | 4.734 |
| 引用数 | 34 |
| WOS 分野 | ENDOCRINOLOGY & METABOLISM BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM 1112 JCM 1131 JCM 1132 JCM 1217 JCM 1255 JCM 1275 JCM 1772 JCM 5826 JCM 5828 JCM 10188 |
| ヒト・動物細胞 | RAW 264(RCB0535) |