| RRC ID |
34763
|
| Author |
Hao YE, He DF, Yin RH, Chen H, Wang J, Wang SX, Zhan YQ, Ge CH, Li CY, Yu M, Yang XM.
|
| Title |
GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice.
|
| Journal |
FEBS Open Bio
|
| Abstract |
G protein-coupled receptor kinase interactor 2 (GIT2) is a signaling scaffold protein involved in regulation of cytoskeletal dynamics and the internalization of G protein-coupled receptors (GPCRs). The short-splice form of GIT2 is expressed in peripheral T cells and thymocytes. However, the functions of GIT2 in T cells have not yet been determined. We show that treatment with Con A in a model of polyclonal T-lymphocyte activation resulted in marked inhibitions in the intrahepatic infiltration of inflammatory cells, cytokine response and acute liver failure in Git2 (-/-) mice. CD4(+) T cells from Git2 (-/-) mice showed significant impairment in proliferation, cytokine production and signal transduction upon TCR-stimulated activation. Our results suggested that GIT2 plays an important role in T-cell function in vivo and in vitro.
|
| Volume |
5
|
| Pages |
688-704
|
| Published |
2015-1-1
|
| DOI |
10.1016/j.fob.2015.08.005
|
| PII |
S2211-5463(15)00078-9
|
| PMID |
26380813
|
| PMC |
PMC4556731
|
| IF |
2.231
|
| Times Cited |
4
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Mice |
RBRC02591 |
