| RRC ID |
34763
|
| 著者 |
Hao YE, He DF, Yin RH, Chen H, Wang J, Wang SX, Zhan YQ, Ge CH, Li CY, Yu M, Yang XM.
|
| タイトル |
GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice.
|
| ジャーナル |
FEBS Open Bio
|
| Abstract |
G protein-coupled receptor kinase interactor 2 (GIT2) is a signaling scaffold protein involved in regulation of cytoskeletal dynamics and the internalization of G protein-coupled receptors (GPCRs). The short-splice form of GIT2 is expressed in peripheral T cells and thymocytes. However, the functions of GIT2 in T cells have not yet been determined. We show that treatment with Con A in a model of polyclonal T-lymphocyte activation resulted in marked inhibitions in the intrahepatic infiltration of inflammatory cells, cytokine response and acute liver failure in Git2 (-/-) mice. CD4(+) T cells from Git2 (-/-) mice showed significant impairment in proliferation, cytokine production and signal transduction upon TCR-stimulated activation. Our results suggested that GIT2 plays an important role in T-cell function in vivo and in vitro.
|
| 巻・号 |
5
|
| ページ |
688-704
|
| 公開日 |
2015-1-1
|
| DOI |
10.1016/j.fob.2015.08.005
|
| PII |
S2211-5463(15)00078-9
|
| PMID |
26380813
|
| PMC |
PMC4556731
|
| IF |
2.231
|
| 引用数 |
4
|
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 実験動物マウス |
RBRC02591 |
