RRC ID 34763
Author Hao YE, He DF, Yin RH, Chen H, Wang J, Wang SX, Zhan YQ, Ge CH, Li CY, Yu M, Yang XM.
Title GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice.
Journal FEBS Open Bio
Abstract G protein-coupled receptor kinase interactor 2 (GIT2) is a signaling scaffold protein involved in regulation of cytoskeletal dynamics and the internalization of G protein-coupled receptors (GPCRs). The short-splice form of GIT2 is expressed in peripheral T cells and thymocytes. However, the functions of GIT2 in T cells have not yet been determined. We show that treatment with Con A in a model of polyclonal T-lymphocyte activation resulted in marked inhibitions in the intrahepatic infiltration of inflammatory cells, cytokine response and acute liver failure in Git2 (-/-) mice. CD4(+) T cells from Git2 (-/-) mice showed significant impairment in proliferation, cytokine production and signal transduction upon TCR-stimulated activation. Our results suggested that GIT2 plays an important role in T-cell function in vivo and in vitro.
Volume 5
Pages 688-704
Published 2015-1-1
DOI 10.1016/j.fob.2015.08.005
PII S2211-5463(15)00078-9
PMID 26380813
PMC PMC4556731
IF 2.231
Times Cited 4
Mice RBRC02591