論文 - 詳細
| RRC ID | 34902 |
|---|---|
| 著者 | Mattila J, Havula E, Suominen E, Teesalu M, Surakka I, Hynynen R, Kilpinen H, Väänänen J, Hovatta I, Käkelä R, Ripatti S, Sandmann T, Hietakangas V. |
| タイトル | Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. |
| ジャーナル | Cell Rep |
| Abstract |
The ChREBP/Mondo-Mlx transcription factors are activated by sugars and are essential for sugar tolerance. They promote the conversion of sugars to lipids, but beyond this, their physiological roles are insufficiently understood. Here, we demonstrate that in an organism-wide setting in Drosophila, Mondo-Mlx controls the majority of sugar-regulated genes involved in nutrient digestion and transport as well as carbohydrate, amino acid, and lipid metabolism. Furthermore, human orthologs of the Mondo-Mlx targets display enrichment among gene variants associated with high circulating triglycerides. In addition to direct regulation of metabolic genes, Mondo-Mlx maintains metabolic homeostasis through downstream effectors, including the Activin ligand Dawdle and the Gli-similar transcription factor Sugarbabe. Sugarbabe controls a subset of Mondo-Mlx-dependent processes, including de novo lipogenesis and fatty acid desaturation. In sum, Mondo-Mlx is a master regulator of other sugar-responsive pathways essential for adaptation to a high-sugar diet. |
| 巻・号 | 13(2) |
| ページ | 350-64 |
| 公開日 | 2015-10-13 |
| DOI | 10.1016/j.celrep.2015.08.081 |
| PII | S2211-1247(15)00994-8 |
| PMID | 26440885 |
| MeSH | Amino Acids / metabolism Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / metabolism* Carbohydrate Metabolism* Carrier Proteins / genetics Carrier Proteins / metabolism Cell Cycle Proteins Drosophila / genetics Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Lipid Metabolism Nuclear Proteins / genetics Nuclear Proteins / metabolism* Transcription Factors / genetics Transcription Factors / metabolism* Transcriptional Activation |
| IF | 8.109 |
| 引用数 | 34 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 3850R-1 3850R-3 |