論文 - 詳細
| RRC ID | 35181 |
|---|---|
| 著者 | Nose A, Mahajan VB, Goodman CS. |
| タイトル | Connectin: a homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in Drosophila. |
| ジャーナル | Cell |
| Abstract |
Each abdominal hemisegment in the Drosophila embryo contains a stereotyped array of 30 muscles, each specifically innervated by one or a few motoneurons. We screened 11,000 enhancer trap lines, isolated several expressing beta-galactosidase in small subsets of muscle fibers prior to innervation, and identified two of these as inserts in connectin and Toll, members of the leucine-rich repeat gene family. Connectin contains a signal sequence, ten leucine-rich repeats, and a putative phosphatidylinositol membrane linkage; in S2 cells, connectin can mediate homophilic cell adhesion. Connectin is expressed on the surface of eight muscles, the motoneurons that innervate them, and several glial cells along the pathways leading to them. During synapse formation, the protein localizes to synaptic sites; afterward, it largely disappears. Thus, connectin is a novel cell adhesion molecule whose expression suggests a role in target recognition. |
| 巻・号 | 70(4) |
| ページ | 553-67 |
| 公開日 | 1992-8-21 |
| DOI | 10.1016/0092-8674(92)90426-d |
| PII | 0092-8674(92)90426-D |
| PMID | 1505024 |
| MeSH | Amino Acid Sequence Animals Base Sequence Cell Adhesion Molecules / analysis Cell Adhesion Molecules / chemistry Cell Adhesion Molecules / genetics* Cloning, Molecular Connectin DNA Drosophila / embryology Drosophila / genetics* Molecular Sequence Data Motor Neurons / chemistry* Muscle Proteins / analysis Muscle Proteins / chemistry Muscle Proteins / genetics* Muscles / chemistry* Muscles / embryology Protein Kinases* Sequence Alignment |
| IF | 38.637 |
| 引用数 | 265 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |