論文 - 詳細
| RRC ID | 35352 |
|---|---|
| 著者 | Dubey GP, Ben-Yehuda S. |
| タイトル | Intercellular nanotubes mediate bacterial communication. |
| ジャーナル | Cell |
| Abstract |
Bacteria are known to communicate primarily via secreted extracellular factors. Here we identify a previously uncharacterized type of bacterial communication mediated by nanotubes that bridge neighboring cells. Using Bacillus subtilis as a model organism, we visualized transfer of cytoplasmic fluorescent molecules between adjacent cells. Additionally, by coculturing strains harboring different antibiotic resistance genes, we demonstrated that molecular exchange enables cells to transiently acquire nonhereditary resistance. Furthermore, nonconjugative plasmids could be transferred from one cell to another, thereby conferring hereditary features to recipient cells. Electron microscopy revealed the existence of variously sized tubular extensions bridging neighboring cells, serving as a route for exchange of intracellular molecules. These nanotubes also formed in an interspecies manner, between B. subtilis and Staphylococcus aureus, and even between B. subtilis and the evolutionary distant bacterium Escherichia coli. We propose that nanotubes represent a major form of bacterial communication in nature, providing a network for exchange of cellular molecules within and between species. |
| 巻・号 | 144(4) |
| ページ | 590-600 |
| 公開日 | 2011-2-18 |
| DOI | 10.1016/j.cell.2011.01.015 |
| PII | S0092-8674(11)00016-X |
| PMID | 21335240 |
| MeSH | Anti-Bacterial Agents / metabolism Bacillus subtilis / metabolism* Bacillus subtilis / ultrastructure* Bacterial Physiological Phenomena Cytoplasm / metabolism Microscopy, Electron, Scanning Nanotubes Plasmids / metabolism Staphylococcus aureus / metabolism |
| IF | 38.637 |
| 引用数 | 273 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 60 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(枯草菌) | |