論文 - 詳細
| RRC ID | 35381 |
|---|---|
| 著者 | Storvik KA, Foster PL. |
| タイトル | The SMC-like protein complex SbcCD enhances DNA polymerase IV-dependent spontaneous mutation in Escherichia coli. |
| ジャーナル | J Bacteriol |
| Abstract |
In Escherichia coli, RpoS, the general stress response sigma factor, regulates the activity of the specialized DNA polymerase DNA polymerase IV (Pol IV) both in stationary-phase and in exponential-phase cells. Because during exponential phase dinB, the gene encoding Pol IV, is transcribed independently of RpoS, RpoS must regulate Pol IV activity in growing cells indirectly via one or more intermediate factors. The results presented here show that one of these intermediate factors is SbcCD, an SMC-like protein and an ATP-dependent nuclease. By initiating or participating in double-strand break repair, SbcCD may provide DNA substrates for Pol IV polymerase activity. |
| 巻・号 | 193(3) |
| ページ | 660-9 |
| 公開日 | 2011-2-1 |
| DOI | 10.1128/JB.01166-10 |
| PII | JB.01166-10 |
| PMID | 21131491 |
| PMC | PMC3021229 |
| MeSH | Bacterial Proteins / genetics Cell Cycle Proteins / genetics DNA Polymerase beta / metabolism* DNA Repair* DNA, Bacterial / metabolism Deoxyribonucleases / genetics Deoxyribonucleases / metabolism* Escherichia coli / genetics Escherichia coli / metabolism* Escherichia coli Proteins / genetics Escherichia coli Proteins / metabolism* Exonucleases / genetics Exonucleases / metabolism* Gene Expression Regulation, Bacterial* Mutation, Missense |
| IF | 3.006 |
| 引用数 | 8 |
| WOS 分野 | MICROBIOLOGY |
| リソース情報 | |
| 原核生物(大腸菌) | Keio collection? |