RRC ID 35426
Author Oh YK, Raj SM, Jung GY, Park S.
Title Current status of the metabolic engineering of microorganisms for biohydrogen production.
Journal Bioresour. Technol.
Abstract The improvement of H2 production capabilities of hydrogen (H2)-producing microorganisms is a challenging issue. Microorganisms have evolved for fast growth and substrate utilization rather than H2 production. To develop good H2-producing biocatalysts, many studies have focused on the redirection and/or reconstruction of cellular metabolisms. These studies included the elimination of enzymes and carbon pathways interfering or competing with H2 production, the incorporation of non-native metabolic pathways leading to H2 production, the utilization of various carbon substrates, the rectification of H2-producting enzymes (nitrogenase and hydrogenase) and photophosphorylation systems, and in silico pathway flux analysis, among others. Owing to these studies, significant improvements in the yield and rate of H2 production, and in the stability of H2 production activity, were reached. This review presents and discusses the recent developments in biohydrogen production, with a focus on metabolic pathway engineering.
Volume 102(18)
Pages 8357-67
Published 2011-9
DOI 10.1016/j.biortech.2011.04.054
PII S0960-8524(11)00568-2
PMID 21733680
MeSH Bacteria / metabolism* Biofuels / analysis* Fermentation / physiology Hydrogen / metabolism* Metabolic Engineering / trends* Photolysis
IF 6.669
Times Cited 60
Prokaryotes E. coli NA