Reference - Detail
| RRC ID | 35427 |
|---|---|
| Author | Hidese R, Mihara H, Kurihara T, Esaki N. |
| Title | Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil. |
| Journal | J Bacteriol |
| Abstract |
The reductive pyrimidine catabolic pathway is absent in Escherichia coli. However, the bacterium contains an enzyme homologous to mammalian dihydropyrimidine dehydrogenase. Here, we show that E. coli dihydropyrimidine dehydrogenase is the first member of a novel NADH-dependent subclass of iron-sulfur flavoenzymes catalyzing the conversion of uracil to 5,6-dihydrouracil in vivo. |
| Volume | 193(4) |
| Pages | 989-93 |
| Published | 2011-2-1 |
| DOI | 10.1128/JB.01178-10 |
| PII | JB.01178-10 |
| PMID | 21169495 |
| PMC | PMC3028684 |
| MeSH | Dihydrouracil Dehydrogenase (NADP) / chemistry Dihydrouracil Dehydrogenase (NADP) / genetics Dihydrouracil Dehydrogenase (NADP) / metabolism* Dimerization Escherichia coli / chemistry Escherichia coli / classification Escherichia coli / enzymology Escherichia coli / metabolism Escherichia coli Proteins / chemistry Escherichia coli Proteins / genetics Escherichia coli Proteins / metabolism* Kinetics Molecular Sequence Data NAD / metabolism* Phylogeny Uracil / analogs & derivatives* Uracil / metabolism |
| IF | 3.006 |
| Times Cited | 17 |
| WOS Category | MICROBIOLOGY |
| Resource | |
| Prokaryotes E. coli | ME7985(W3110) JW2133(Keio)(ASKA)? |