Reference - Detail
| RRC ID | 35475 |
|---|---|
| Author | Cendra Mdel M, Juárez A, Torrents E. |
| Title | Biofilm modifies expression of ribonucleotide reductase genes in Escherichia coli. |
| Journal | PLoS One |
| Abstract |
Ribonucleotide reductase (RNR) is an essential enzyme for all living organisms since is the responsible for the last step in the synthesis of the four deoxyribonucleotides (dNTPs) necessary for DNA replication and repair. In this work, we have investigated the expression of the three-RNR classes (Ia, Ib and III) during Escherichia coli biofilm formation. We show the temporal and spatial importance of class Ib and III RNRs during this process in two different E. coli wild-type strains, the commensal MG1655 and the enteropathogenic and virulent E2348/69, the prototype for the enteropathogenic E. coli (EPEC). We have established that class Ib RNR, so far considered cryptic, play and important role during biofilm formation. The implication of this RNR class under the specific growth conditions of biofilm formation is discussed. |
| Volume | 7(9) |
| Pages | e46350 |
| Published | 2012-1-1 |
| DOI | 10.1371/journal.pone.0046350 |
| PII | PONE-D-12-03894 |
| PMID | 23050019 |
| PMC | PMC3458845 |
| MeSH | Biofilms / growth & development* Escherichia coli / enzymology* Escherichia coli / growth & development* Escherichia coli Proteins / genetics Escherichia coli Proteins / metabolism* Ribonucleotide Reductases / genetics Ribonucleotide Reductases / metabolism* |
| IF | 2.74 |
| Times Cited | 11 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Wikipedia |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Prokaryotes E. coli | JW2650-KC JW4197-KC JW5437-KC |