論文 - 詳細
| RRC ID | 35493 |
|---|---|
| 著者 | Schuetz R, Zamboni N, Zampieri M, Heinemann M, Sauer U. |
| タイトル | Multidimensional optimality of microbial metabolism. |
| ジャーナル | Science |
| Abstract |
Although the network topology of metabolism is well known, understanding the principles that govern the distribution of fluxes through metabolism lags behind. Experimentally, these fluxes can be measured by (13)C-flux analysis, and there has been a long-standing interest in understanding this functional network operation from an evolutionary perspective. On the basis of (13)C-determined fluxes from nine bacteria and multi-objective optimization theory, we show that metabolism operates close to the Pareto-optimal surface of a three-dimensional space defined by competing objectives. Consistent with flux data from evolved Escherichia coli, we propose that flux states evolve under the trade-off between two principles: optimality under one given condition and minimal adjustment between conditions. These principles form the forces by which evolution shapes metabolic fluxes in microorganisms' environmental context. |
| 巻・号 | 336(6081) |
| ページ | 601-4 |
| 公開日 | 2012-5-4 |
| DOI | 10.1126/science.1216882 |
| PII | 336/6081/601 |
| PMID | 22556256 |
| MeSH | Adaptation, Physiological Adenosine Triphosphate / metabolism Aerobiosis Algorithms Bacteria / growth & development Bacteria / metabolism* Biological Evolution* Biomass Computer Simulation Escherichia coli / genetics Escherichia coli / growth & development Escherichia coli / metabolism* Glucose / metabolism Metabolic Networks and Pathways* Models, Biological |
| IF | 41.846 |
| 引用数 | 228 |
| WOS 分野 | MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 41 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 原核生物(大腸菌) | |