論文 - 詳細
| RRC ID | 35744 |
|---|---|
| 著者 | Raveney BJ, Oki S, Hohjoh H, Nakamura M, Sato W, Murata M, Yamamura T. |
| タイトル | Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation. |
| ジャーナル | Nat Commun |
| Abstract |
Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T cells, a late-onset disease is still inducible, despite a great reduction in acute inflammation. We here reveal that development of this late onset disease depends on cytotoxic T-cell-like CD4(+) T cells expressing the T-box transcription factor Eomesodermin (Eomes). T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset EAE. Strikingly, similar Eomes(+) CD4(+) T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis. Collective data indicate an involvement of granzyme B and protease-activated receptor-1 in the neuroinflammation mediated by Eomes(+) CD4(+) T cells. |
| 巻・号 | 6 |
| ページ | 8437 |
| 公開日 | 2015-10-5 |
| DOI | 10.1038/ncomms9437 |
| PII | ncomms9437 |
| PMID | 26436530 |
| PMC | PMC4600741 |
| MeSH | Adult Animals Encephalomyelitis, Autoimmune, Experimental / genetics Encephalomyelitis, Autoimmune, Experimental / immunology* Female Granzymes / immunology* Humans Male Mice Middle Aged Multiple Sclerosis, Chronic Progressive / immunology* Multiple Sclerosis, Relapsing-Remitting / immunology Nuclear Receptor Subfamily 4, Group A, Member 2 / immunology Receptor, PAR-1 / immunology* T-Box Domain Proteins / genetics T-Box Domain Proteins / immunology* T-Lymphocytes, Helper-Inducer / immunology Th17 Cells / immunology* Young Adult |
| IF | 12.121 |
| 引用数 | 35 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 19 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 3.0 |
| リソース情報 | |
| 実験動物マウス | RBRC01834 |