RRC ID 35744
Author Raveney BJ, Oki S, Hohjoh H, Nakamura M, Sato W, Murata M, Yamamura T.
Title Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation.
Journal Nat Commun
Abstract Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T cells, a late-onset disease is still inducible, despite a great reduction in acute inflammation. We here reveal that development of this late onset disease depends on cytotoxic T-cell-like CD4(+) T cells expressing the T-box transcription factor Eomesodermin (Eomes). T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset EAE. Strikingly, similar Eomes(+) CD4(+) T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis. Collective data indicate an involvement of granzyme B and protease-activated receptor-1 in the neuroinflammation mediated by Eomes(+) CD4(+) T cells.
Volume 6
Pages 8437
Published 2015-10-5
DOI 10.1038/ncomms9437
PII ncomms9437
PMID 26436530
PMC PMC4600741
MeSH Adult Animals Encephalomyelitis, Autoimmune, Experimental / genetics Encephalomyelitis, Autoimmune, Experimental / immunology* Female Granzymes / immunology* Humans Male Mice Middle Aged Multiple Sclerosis, Chronic Progressive / immunology* Multiple Sclerosis, Relapsing-Remitting / immunology Nuclear Receptor Subfamily 4, Group A, Member 2 / immunology Receptor, PAR-1 / immunology* T-Box Domain Proteins / genetics T-Box Domain Proteins / immunology* T-Lymphocytes, Helper-Inducer / immunology Th17 Cells / immunology* Young Adult
IF 12.121
Times Cited 35
Mice RBRC01834