| RRC ID |
35744
|
| Author |
Raveney BJ, Oki S, Hohjoh H, Nakamura M, Sato W, Murata M, Yamamura T.
|
| Title |
Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation.
|
| Journal |
Nat Commun
|
| Abstract |
Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T cells, a late-onset disease is still inducible, despite a great reduction in acute inflammation. We here reveal that development of this late onset disease depends on cytotoxic T-cell-like CD4(+) T cells expressing the T-box transcription factor Eomesodermin (Eomes). T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset EAE. Strikingly, similar Eomes(+) CD4(+) T cells are increased in the peripheral blood and cerebrospinal fluid from patients in a progressive state of multiple sclerosis. Collective data indicate an involvement of granzyme B and protease-activated receptor-1 in the neuroinflammation mediated by Eomes(+) CD4(+) T cells.
|
| Volume |
6
|
| Pages |
8437
|
| Published |
2015-10-5
|
| DOI |
10.1038/ncomms9437
|
| PII |
ncomms9437
|
| PMID |
26436530
|
| PMC |
PMC4600741
|
| MeSH |
Adult
Animals
Encephalomyelitis, Autoimmune, Experimental / genetics
Encephalomyelitis, Autoimmune, Experimental / immunology*
Female
Granzymes / immunology*
Humans
Male
Mice
Middle Aged
Multiple Sclerosis, Chronic Progressive / immunology*
Multiple Sclerosis, Relapsing-Remitting / immunology
Nuclear Receptor Subfamily 4, Group A, Member 2 / immunology
Receptor, PAR-1 / immunology*
T-Box Domain Proteins / genetics
T-Box Domain Proteins / immunology*
T-Lymphocytes, Helper-Inducer / immunology
Th17 Cells / immunology*
Young Adult
|
| IF |
12.121
|
| Times Cited |
35
|
|
WOS Category
|
IMMUNOLOGY
|
| Resource |
| Mice |
RBRC01834 |
