Reference - Detail
| RRC ID | 35776 |
|---|---|
| Author | Yachida S, Wood LD, Suzuki M, Takai E, Totoki Y, Kato M, Luchini C, Arai Y, Nakamura H, Hama N, Elzawahry A, Hosoda F, Shirota T, Morimoto N, Hori K, Funazaki J, Tanaka H, Morizane C, Okusaka T, Nara S, Shimada K, Hiraoka N, Taniguchi H, Higuchi R, Oshima M, Okano K, Hirono S, Mizuma M, Arihiro K, Yamamoto M, Unno M, Yamaue H, Weiss MJ, Wolfgang CL, Furukawa T, Nakagama H, Vogelstein B, Kiyono T, Hruban RH, Shibata T. |
| Title | Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma. |
| Journal | Cancer Cell |
| Abstract |
Ampullary carcinomas are highly malignant neoplasms that can have either intestinal or pancreatobiliary differentiation. To characterize somatic alterations in ampullary carcinomas, we performed whole-exome sequencing and DNA copy-number analysis on 60 ampullary carcinomas resected from clinically well-characterized Japanese and American patients. We next selected 92 genes and performed targeted sequencing to validate significantly mutated genes in an additional 112 cancers. The prevalence of driver gene mutations in carcinomas with the intestinal phenotype is different from those with the pancreatobiliary phenotype. We identified a characteristic significantly mutated driver gene (ELF3) as well as previously known driver genes (TP53, KRAS, APC, and others). Functional studies demonstrated that ELF3 silencing in normal human epithelial cells enhances their motility and invasion. |
| Volume | 29(2) |
| Pages | 229-40 |
| Published | 2016-2-8 |
| DOI | 10.1016/j.ccell.2015.12.012 |
| PII | S1535-6108(15)00476-6 |
| PMID | 26806338 |
| PMC | PMC5503303 |
| MeSH | Adult Aged Aged, 80 and over DNA-Binding Proteins / genetics* Exome Female Humans Male Middle Aged Pancreatic Neoplasms / genetics* Proto-Oncogene Proteins c-ets / genetics* Transcription Factors / genetics* Young Adult |
| IF | 26.602 |
| Times Cited | 52 |
| WOS Category | ONCOLOGY CELL BIOLOGY |
| Resource | |
| DNA material | CSII-CMV-RfA (RDB04386) |