論文 - 詳細
| RRC ID | 36039 |
|---|---|
| 著者 | Lv X, Han Z, Chen H, Yang B, Yang X, Xia Y, Pan C, Fu L, Zhang S, Han H, Wu M, Zhou Z, Zhang L, Li L, Wei G, Zhao Y. |
| タイトル | A positive role for polycomb in transcriptional regulation via H4K20me1. |
| ジャーナル | Cell Res |
| Abstract |
The highly conserved polycomb group (PcG) proteins maintain heritable transcription repression of the genes essential for development from fly to mammals. However, sporadic reports imply a potential role of PcGs in positive regulation of gene transcription, although systematic investigation of such function and the underlying mechanism has rarely been reported. Here, we report a Pc-mediated, H3K27me3-dependent positive transcriptional regulation of Senseless (Sens), a key transcription factor required for development. Mechanistic studies show that Pc regulates Sens expression by promoting H4K20me1 at the Sens locus. Further bioinformatic analysis at genome-wide level indicates that the existence of H4K20me1 acts as a selective mark for positive transcriptional regulation by Pc/H3K27me3. Both the intensities and specific patterns of Pc and H3K27me3 are important for the fates of target gene transcription. Moreover, binding of transcription factor Broad (Br), which physically interacts with Pc and positively regulates the transcription of Sens, is observed in Pc(+)H3K27me3(+)H4K20me1(+) genes, but not in Pc(+)H3K27me3(+)H4K20me1(-) genes. Taken together, our study reveals that, coupling with the transcription factor Br, Pc positively regulates transcription of Pc(+)H3K27me3(+)H4K20me1(+) genes in developing Drosophila wing disc. |
| 巻・号 | 26(5) |
| ページ | 529-42 |
| 公開日 | 2016-5-1 |
| DOI | 10.1038/cr.2016.33 |
| PII | cr201633 |
| PMID | 27002220 |
| PMC | PMC4856762 |
| MeSH | Animals Base Sequence Biomarkers / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / embryology Drosophila melanogaster / genetics* Gene Expression Regulation, Developmental* Histones / metabolism* Lysine / metabolism* Methylation Nuclear Proteins / genetics Polycomb Repressive Complex 1 / metabolism* Repressor Proteins / metabolism Transcription Factors / genetics Transcription, Genetic Wings, Animal / metabolism |
| IF | 20.507 |
| 引用数 | 9 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 32443R-4 6502R-4 3307R-1 |