RRC ID 36124
Author Sieber MH, Thomsen MB, Spradling AC.
Title Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction.
Journal Cell
Abstract Reproduction is heavily influenced by nutrition and metabolic state. Many common reproductive disorders in humans are associated with diabetes and metabolic syndrome. We characterized the metabolic mechanisms that support oogenesis and found that mitochondria in mature Drosophila oocytes enter a low-activity state of respiratory quiescence by remodeling the electron transport chain (ETC). This shift in mitochondrial function leads to extensive glycogen accumulation late in oogenesis and is required for the developmental competence of the oocyte. Decreased insulin signaling initiates ETC remodeling and mitochondrial respiratory quiescence through glycogen synthase kinase 3 (GSK3). Intriguingly, we observed similar ETC remodeling and glycogen uptake in maturing Xenopus oocytes, suggesting that these processes are evolutionarily conserved aspects of oocyte development. Our studies reveal an important link between metabolism and oocyte maturation.
Volume 164(3)
Pages 420-32
Published 2016-1-28
DOI 10.1016/j.cell.2015.12.020
PII S0092-8674(15)01684-0
PMID 26824655
PMC PMC6894174
MeSH Animals Drosophila Proteins / metabolism* Drosophila melanogaster / embryology* Drosophila melanogaster / metabolism Electron Transport Chain Complex Proteins / metabolism* Embryo, Nonmammalian / metabolism Embryonic Development Female Forkhead Transcription Factors / metabolism Glycogen / metabolism* Glycogen Synthase Kinase 3 / metabolism* Mitochondria / metabolism Oncogene Protein v-akt / metabolism Oocytes / cytology Oocytes / metabolism Oogenesis* Xenopus laevis / embryology* Xenopus laevis / metabolism
IF 38.637
Times Cited 44
WOS Category BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
Resource
Drosophila DGRC#204216