論文 - 詳細
| RRC ID | 36168 |
|---|---|
| 著者 | Lim YM, Yagi Y, Tsuda L. |
| タイトル | Cellular Defense and Sensory Cell Survival Require Distinct Functions of ebi in Drosophila. |
| ジャーナル | PLoS One |
| Abstract |
The innate immune response and stress-induced apoptosis are well-established signaling pathways related to cellular defense. NF-κB and AP-1 are redox-sensitive transcription factors that play important roles in those pathways. Here we show that Ebi, a Drosophila homolog of the mammalian co-repressor molecule transducin β-like 1 (TBL1), variously regulates the expression of specific genes that are targets of redox-sensitive transcription factors. In response to different stimuli, Ebi activated gene expression to support the acute immune response in fat bodies, whereas Ebi repressed genes that are involved in apoptosis in photoreceptor cells. Thus, Ebi seems to act as a regulatory switch for genes that are activated or repressed in response to different external stimuli. Our results offer clear in vivo evidence that the Ebi-containing co-repressor complex acts in a distinct manner to regulate transcription that is required for modulating the output of various processes during Drosophila development. |
| 巻・号 | 10(11) |
| ページ | e0141457 |
| 公開日 | 2015-11-2 |
| DOI | 10.1371/journal.pone.0141457 |
| PII | PONE-D-15-13696 |
| PMID | 26524764 |
| PMC | PMC4629896 |
| MeSH | Animals Apoptosis Cell Cycle Proteins / metabolism* Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / immunology* Fat Body / immunology* GTP-Binding Proteins / metabolism* Gene Expression Regulation Immunity, Innate Oxidation-Reduction Photoreceptor Cells, Invertebrate / cytology Promoter Regions, Genetic Signal Transduction Transcription, Genetic |
| IF | 2.74 |
| 引用数 | 2 |
| WOS 分野 | CELL BIOLOGY |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 7 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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