論文 - 詳細
| RRC ID | 36284 |
|---|---|
| 著者 | Xing Y, Su TT, Ruohola-Baker H. |
| タイトル | Tie-mediated signal from apoptotic cells protects stem cells in Drosophila melanogaster. |
| ジャーナル | Nat Commun |
| Abstract |
Many types of normal and cancer stem cells are resistant to killing by genotoxins, but the mechanism for this resistance is poorly understood. Here we show that adult stem cells in Drosophila melanogaster germline and midgut are resistant to ionizing radiation (IR) or chemically induced apoptosis and dissect the mechanism for this protection. We find that upon IR the receptor tyrosine kinase Tie/Tie-2 is activated, leading to the upregulation of microRNA bantam that represses FOXO-mediated transcription of pro-apoptotic Smac/DIABLO orthologue, Hid in germline stem cells. Knockdown of the IR-induced putative Tie ligand, Pvf1, a functional homologue of human Angiopoietin, in differentiating daughter cells renders germline stem cells sensitive to IR, suggesting that the dying daughters send a survival signal to protect their stem cells for future repopulation of the tissue. If conserved in cancer stem cells, this mechanism may provide therapeutic options for the eradication of cancer. |
| 巻・号 | 6 |
| ページ | 7058 |
| 公開日 | 2015-5-11 |
| DOI | 10.1038/ncomms8058 |
| PII | ncomms8058 |
| PMID | 25959206 |
| PMC | PMC4451836 |
| MeSH | Animals Apoptosis / physiology* Drosophila melanogaster / metabolism* Gene Deletion Gene Expression Regulation, Enzymologic / physiology* Radiation, Ionizing Receptor, TIE-2 Receptors, TIE / genetics Receptors, TIE / metabolism* Signal Transduction Stem Cells / physiology* |
| IF | 12.121 |
| 引用数 | 23 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#114544 |