Reference - Detail
| RRC ID | 36356 |
|---|---|
| Author | Matsumoto Y, Sekimizu K. |
| Title | A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine. |
| Journal | Drug Discov Ther |
| Abstract |
Silkworm shows hyperglycemia after intake of diet containing large amount of glucose. The hyperglycemic silkworm model is useful for evaluation of anti-diabetic drugs. A hot water extract of Rehmanniae Radix, an herbal medicine, showed hypoglycemic effect against the hyperglycemic silkworms. This method is applicable for quick and simple evaluation of the hypoglycemic activities of different batches of Rehmanniae Radix. Our findings suggest that silkworms have a lot of merit as experimental animals for evaluation of various herbal medicines. |
| Volume | 10(1) |
| Pages | 14-8 |
| Published | 2016-2-1 |
| DOI | 10.5582/ddt.2016.01016 |
| PMID | 26902904 |
| MeSH | Animals Bombyx / drug effects* Bombyx / embryology Bombyx / metabolism Diabetes Mellitus / drug therapy* Diabetes Mellitus / metabolism Disease Models, Animal Drug Discovery / methods* Glucose / metabolism* Humans Hypoglycemic Agents / isolation & purification Hypoglycemic Agents / pharmacology* Larva / drug effects Larva / metabolism Phytotherapy Plant Extracts / isolation & purification Plant Extracts / pharmacology* Plants, Medicinal Rehmannia / chemistry* Species Specificity |
| Times Cited | 2 |
| Resource | |
| Silkworms | |