論文 - 詳細
| RRC ID | 36357 |
|---|---|
| 著者 | Ishii M, Matsumoto Y, Sekimizu K. |
| タイトル | Usefulness of silkworm as a host animal for understanding pathogenicity of Cryptococcus neoformans. |
| ジャーナル | Drug Discov Ther |
| Abstract |
We propose Cryptococcus neoformans infection model using silkworm for understanding cryptococcosis and screening of therapeutically effective antibiotics. Silkworm is an insect whose rearing methods were established through a long history of the sericulture industry. Silkworm facilitates experiments using a large number of individuals because of low cost for rearing and few ethical problems caused by killing animals. Silkworm can be reared at 37˚C to perform infection experiments at same temperature to human body. Injection of accurate amounts of samples into hemolymph of silkworm by usual syringes is easy to be done since silkworm has an appropriate size to handle. Moreover two injection methods, injection into hemolymph and intestine, are distinguishable for silkworms. The former is correspondent to intravenous injection, and the latter is to oral administration in humans. Taking these advantages of silkworms as host animals, it is possible to evaluate the virulence factors in C. neoformans and the therapeutic efficacy of antifungal agents. |
| 巻・号 | 10(1) |
| ページ | 9-13 |
| 公開日 | 2016-2-1 |
| DOI | 10.5582/ddt.2016.01015 |
| PMID | 26902902 |
| MeSH | Animals Anti-Bacterial Agents / pharmacology Bombyx / drug effects Bombyx / embryology Bombyx / microbiology* Cryptococcosis / drug therapy Cryptococcosis / microbiology* Cryptococcus neoformans / drug effects Cryptococcus neoformans / pathogenicity* Disease Models, Animal Drug Discovery / methods Humans Larva Species Specificity Virulence |
| 引用数 | 11 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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