RRC ID 36518
著者 Muralimanoharan S, Gao X, Weintraub S, Myatt L, Maloyan A.
タイトル Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model.
ジャーナル Autophagy
Abstract The incidence of maternal obesity and its co-morbidities (diabetes, cardiovascular disease) continues to increase at an alarming rate, with major public health implications. In utero exposure to maternal obesity has been associated with development of cardiovascular and metabolic diseases in the offspring as a result of developmental programming. The placenta regulates maternal-fetal metabolism and shows significant changes in its function with maternal obesity. Autophagy is a cell-survival process, which is responsible for the degradation of damaged organelles and misfolded proteins. Here we show an activation of autophagosomal formation and autophagosome-lysosome fusion in placentas of males but not females from overweight (OW) and obese (OB) women vs. normal weight (NW) women. However, total autophagic activity in these placentas appeared to be decreased as it showed an increase in SQSTM1/p62 and a decrease in lysosomal biogenesis. A mouse model with a targeted deletion of the essential autophagy gene Atg7 in placental tissue showed significant placental abnormalities comparable to those seen in human placenta with maternal obesity. These included a decrease in expression of mitochondrial genes and antioxidants, and decreased lysosomal biogenesis. Strikingly, the knockout mice were developmentally programmed as they showed an increased sensitivity to high-fat diet-induced obesity, hyperglycemia, hyperinsulinemia, increased adiposity, and cardiac remodeling. In summary, our results indicate a sexual dimorphism in placental autophagy in response to maternal obesity. We also show that autophagy plays an important role in placental function and that inhibition of placental autophagy programs the offspring to obesity, and to metabolic and cardiovascular diseases.
巻・号 12(5)
ページ 752-69
公開日 2016-5-3
DOI 10.1080/15548627.2016.1156822
PMID 26986453
PMC PMC4854539
MeSH Animals Autophagy / genetics Autophagy / physiology* Diet, High-Fat / adverse effects Disease Models, Animal Female Fetal Development / genetics* Humans Mice, Knockout Obesity / complications* Obesity / metabolism Placenta* / metabolism Pregnancy Sex Characteristics*
IF 9.77
引用数 25
WOS 分野 CELL BIOLOGY
リソース情報
実験動物マウス RBRC02759