論文 - 詳細
| RRC ID | 36668 |
|---|---|
| 著者 | Yamashita-Kanemaru Y, Takahashi Y, Wang Y, Tahara-Hanaoka S, Honda S, Bernhardt G, Shibuya A, Shibuya K. |
| タイトル | CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation. |
| ジャーナル | J Immunol |
| Abstract |
Although Th1 and Th2 cells are known to be involved in allergic inflammatory diseases, the molecular mechanisms underlying their differentiation are incompletely understood. In this study, we identified CD155 as a costimulatory molecule on CD4(+) T cells. Importantly, CD155-mediated signaling induced Th1 development in both humans and mice, as evidenced by production of IFN-γ and upregulation of Tbx21 transcription; these effects were independent of IL-12 but dependent on NF-κB-induced autocrine IFN-γ that triggered positive feedback via STAT1 activation. Mice genetically deficient in CD155 or treated with anti-CD155 Ab exhibited attenuated Th1-type contact hypersensitivity. Thus, CD155 plays an important regulatory role in helper T cell differentiation and allergic diseases. |
| 巻・号 | 194(12) |
| ページ | 5644-53 |
| 公開日 | 2015-6-15 |
| DOI | 10.4049/jimmunol.1401942 |
| PII | jimmunol.1401942 |
| PMID | 25972481 |
| MeSH | Animals Antibodies, Monoclonal / administration & dosage Antibodies, Monoclonal / pharmacology CD4-Positive T-Lymphocytes / immunology* CD4-Positive T-Lymphocytes / metabolism* Dermatitis, Contact / drug therapy Dermatitis, Contact / immunology Dermatitis, Contact / metabolism Disease Models, Animal Humans Hypersensitivity / drug therapy Hypersensitivity / immunology* Hypersensitivity / metabolism* Interferon-gamma / metabolism Interleukin-12 / metabolism Mice Mice, Knockout Phosphorylation Receptors, Virus / antagonists & inhibitors Receptors, Virus / genetics Receptors, Virus / metabolism* Signal Transduction* Th1 Cells / immunology Th1 Cells / metabolism |
| IF | 4.886 |
| 引用数 | 7 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 17 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 研究用ヒト臍帯血幹細胞 | 研究用ヒト臍帯血幹細胞 |