| RRC ID |
36668
|
| 著者 |
Yamashita-Kanemaru Y, Takahashi Y, Wang Y, Tahara-Hanaoka S, Honda S, Bernhardt G, Shibuya A, Shibuya K.
|
| タイトル |
CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation.
|
| ジャーナル |
J Immunol
|
| Abstract |
Although Th1 and Th2 cells are known to be involved in allergic inflammatory diseases, the molecular mechanisms underlying their differentiation are incompletely understood. In this study, we identified CD155 as a costimulatory molecule on CD4(+) T cells. Importantly, CD155-mediated signaling induced Th1 development in both humans and mice, as evidenced by production of IFN-γ and upregulation of Tbx21 transcription; these effects were independent of IL-12 but dependent on NF-κB-induced autocrine IFN-γ that triggered positive feedback via STAT1 activation. Mice genetically deficient in CD155 or treated with anti-CD155 Ab exhibited attenuated Th1-type contact hypersensitivity. Thus, CD155 plays an important regulatory role in helper T cell differentiation and allergic diseases.
|
| 巻・号 |
194(12)
|
| ページ |
5644-53
|
| 公開日 |
2015-6-15
|
| DOI |
10.4049/jimmunol.1401942
|
| PII |
jimmunol.1401942
|
| PMID |
25972481
|
| MeSH |
Animals
Antibodies, Monoclonal / administration & dosage
Antibodies, Monoclonal / pharmacology
CD4-Positive T-Lymphocytes / immunology*
CD4-Positive T-Lymphocytes / metabolism*
Dermatitis, Contact / drug therapy
Dermatitis, Contact / immunology
Dermatitis, Contact / metabolism
Disease Models, Animal
Humans
Hypersensitivity / drug therapy
Hypersensitivity / immunology*
Hypersensitivity / metabolism*
Interferon-gamma / metabolism
Interleukin-12 / metabolism
Mice
Mice, Knockout
Phosphorylation
Receptors, Virus / antagonists & inhibitors
Receptors, Virus / genetics
Receptors, Virus / metabolism*
Signal Transduction*
Th1 Cells / immunology
Th1 Cells / metabolism
|
| IF |
4.886
|
| 引用数 |
7
|
|
WOS 分野
|
IMMUNOLOGY
|
| リソース情報 |
| 研究用ヒト臍帯血幹細胞 |
研究用ヒト臍帯血幹細胞 |
