| RRC ID |
36670
|
| Author |
Jasirwan C, Tang H, Kawabata A, Mori Y.
|
| Title |
The human herpesvirus 6 U21-U24 gene cluster is dispensable for virus growth.
|
| Journal |
Microbiol Immunol
|
| Abstract |
Human herpesvirus 6 (HHV-6) is a T-lymphotrophic virus belongs to the genus Roseolovirus within the beta herpesvirus subfamily. The U20-U24 gene cluster is unique to Roseoloviruses; however, both their function and whether they are essential for virus growth is unknown. Recently, bacterial artificial chromosome (BAC) techniques have been used to investigate HHV-6A. This study describes generation of a virus genome lacking U21-U24 (HHV-6ABACΔU21-24) and shows that infectious virus particles can be reconstituted from this BAC DNA. Our data indicate that the HHV-6 U21-U24 gene cluster is dispensable for virus propagation.
|
| Volume |
59(1)
|
| Pages |
48-53
|
| Published |
2015-1-1
|
| DOI |
10.1111/1348-0421.12208
|
| PMID |
25346365
|
| MeSH |
Chromosomes, Artificial, Bacterial
Gene Deletion
Genes, Viral*
Herpesvirus 6, Human / genetics
Herpesvirus 6, Human / growth & development
Herpesvirus 6, Human / physiology*
Multigene Family*
Reverse Genetics
Viral Proteins / genetics
Viral Proteins / metabolism*
Virion / physiology
Virus Replication*
|
| IF |
1.566
|
| Times Cited |
2
|
|
WOS Category
|
IMMUNOLOGY
MICROBIOLOGY
|
| Resource |
| Cord blood stem cells for research |
研究用ヒト臍帯血幹細胞 |
