RRC ID 36676
Author Mahmoud NF, Kawabata A, Tang H, Wakata A, Wang B, Serada S, Naka T, Mori Y.
Title Human herpesvirus 6 U11 protein is critical for virus infection.
Journal Virology
Abstract All herpesviruses contain a tegument layer comprising a protein matrix; these proteins play key roles during viral assembly and egress. Here, liquid chromatography and tandem mass spectrometry analysis (LC-MS/MS) of proteins from human herpesvirus 6 (HHV-6)-infected cells revealed a possible association between two major tegument proteins, U14 and U11. This association was verified by immunoprecipitation experiments. Moreover, U11 protein was expressed during the late phase of infection and incorporated into virions. Finally, in contrast to its revertant, a U11 deletion mutant could not be reconstituted. Taken together, these results suggest that HHV-6 U11 is an essential gene for virus growth and propagation.
Volume 489
Pages 151-7
Published 2016-2-1
DOI 10.1016/j.virol.2015.12.011
PII S0042-6822(15)00532-2
PMID 26761397
MeSH Herpesvirus 6, Human / genetics Herpesvirus 6, Human / growth & development Herpesvirus 6, Human / metabolism* Humans Protein Binding Roseolovirus Infections / virology* Viral Structural Proteins / genetics Viral Structural Proteins / metabolism*
IF 2.819
Times Cited 6
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