RRC ID 36875
著者 Sato A, Tamura H.
タイトル High antiallergic activity of 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone and 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone from eau de cologne mint (Mentha×piperita citrata).
ジャーナル Fitoterapia
Abstract The following compounds with higher antiallergic activities were isolated from eau de cologne mint leaves: 5,6,4'-trihydroxy-7,8-dimethoxyflavone (6), 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone (7), 5,6-dihydroxy-7,3',4'-trimethoxyflavone (8), 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone (9), and 5,6-dihydroxy-7,8,4'-trimethoxyflavone (10). The IC50 values of compounds 6-10 against RBL-2H3 cells were 6.7, 2.4, 5.6, 3.0, and 6.1μM. Compounds 7 and 9 (IC50 2.4μM and 3.0μM) had the highest antiallergic activities among the flavonoids previously reported. The amounts of 7, 9, and 10 isolated were fairly high, at 177.7mg/kg, 278.0mg/kg, and 179.7mg/kg in the mint, respectively. LD5 value (index of toxicity) and LD5/IC50 ratio of 7 and 9 indicate that the safety is greater than that of luteolin, a typical antiallergic substance. The extract containing powerful antiallergic flavones, 6-10 with higher hydrophobicity could be selectively separated from the extract containing luteolin and other flavonoid glycosides by partition with dichloromethane and water. Therefore, compounds 7 and 9 in mint, and the dichloromethane extract would be the most potent and preventive resources against type I allergy.
巻・号 102
ページ 74-83
公開日 2015-4-1
DOI 10.1016/j.fitote.2015.02.003
PII S0367-326X(15)00036-2
PMID 25704366
MeSH Animals Anti-Allergic Agents / chemistry* Anti-Allergic Agents / isolation & purification Cell Line, Tumor Flavones / chemistry* Flavones / isolation & purification Mentha piperita / chemistry* Molecular Structure Plant Extracts / chemistry* Plant Leaves / chemistry Rats
IF 2.527
引用数 9
WOS 分野 PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL
リソース情報
ヒト・動物細胞 RBL 2H3(RCB2782)