論文 - 詳細
| RRC ID | 36884 |
|---|---|
| 著者 | Kawabata K, Kato Y, Sakano T, Baba N, Hagiwara K, Tamura A, Baba S, Natsume M, Ohigashi H. |
| タイトル | Effects of phytochemicals on in vitro anti-inflammatory activity of Bifidobacterium adolescentis. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
Probiotics have been shown to improve the condition of not only the human gastrointestinal tract but also the entire body. We found that quercetin enhances the anti-inflammatory activity of Bifidobacterium adolescentis, which is abundant in human intestines. Here, we assessed whether certain phytochemicals could enhance the anti-inflammatory activity of B. adolescentis. Bifidobacteria were anaerobically cultured with phytochemicals for 3 h, and the anti-inflammatory activity of the supernatants was estimated by testing their ability to inhibit nitric oxide (NO) production by lipopolysaccharide-stimulated RAW264 macrophages. Of the 55 phytochemicals tested, phloretin, (+)-taxifolin, and (-)-epigallocatechin gallate as well as quercetin-3-O-glucoside and quercetin-4'-O-glucoside were similar to quercetin in promoting NO suppression by B. adolescentis. In addition, the phytochemicals excluding quercetin increased the concentrations of lactic and acetic acids in the co-culture supernatants. These results suggest that some phytochemicals may activate the anti-inflammatory function of B. adolescentis. |
| 巻・号 | 79(5) |
| ページ | 799-807 |
| 公開日 | 2015-1-1 |
| DOI | 10.1080/09168451.2015.1006566 |
| PMID | 25721815 |
| MeSH | Acetic Acid / metabolism Animals Anti-Inflammatory Agents / pharmacology* Bifidobacterium* / drug effects Bifidobacterium* / physiology Catechin / analogs & derivatives Catechin / pharmacology Cell Line / drug effects Coculture Techniques Dose-Response Relationship, Drug Flavonoids Glucosides Lactic Acid / metabolism Lipopolysaccharides / pharmacology Macrophages / drug effects Mice Nitric Oxide / metabolism Phytochemicals / pharmacology Probiotics / pharmacology* Quercetin / analogs & derivatives Quercetin / pharmacology |
| IF | 1.516 |
| 引用数 | 7 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY BIOTECHNOLOGY & APPLIED MICROBIOLOGY CHEMISTRY, APPLIED BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |