| RRC ID |
36909
|
| Author |
Raveendran S, Palaninathan V, Nagaoka Y, Fukuda T, Iwai S, Higashi T, Mizuki T, Sakamoto Y, Mohanan PV, Maekawa T, Kumar DS.
|
| Title |
Extremophilic polysaccharide nanoparticles for cancer nanotherapy and evaluation of antioxidant properties.
|
| Journal |
Int J Biol Macromol
|
| Abstract |
Polysaccharides that show finest bioactivities and physicochemical properties are always promising for bionanoscience applications. Mauran is such a macromolecule extracted from halophilic bacterium, Halomonas maura for biotechnology and nanoscience applications. Antioxidant properties of MR/CH nanoparticles were studied using biochemical assays to prove the versatility of these test nanoparticles for biomedical applications. Here, we demonstrate the prospects of extremophilic polysaccharide, mauran based nanoparticles for scavenging reactive oxygen species in both in vitro and ex vivo conditions. 5-fluorouracil loaded MR/CH nanoparticles were tested for anticancer proliferation and compared their therapeutic efficiency using breast adenocarcinoma and glioma cells. Fluorescently labeled nanoparticles were employed to show the cellular uptake of these nanocarriers using confocal microscopic imaging and flow cytometry.
|
| Volume |
76
|
| Pages |
310-9
|
| Published |
2015-5-1
|
| DOI |
10.1016/j.ijbiomac.2015.03.001
|
| PII |
S0141-8130(15)00135-X
|
| PMID |
25749105
|
| MeSH |
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Antioxidants / chemistry*
Antioxidants / pharmacology*
Cell Line, Tumor
Halomonas / chemistry*
Humans
Nanoparticles / administration & dosage
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Polysaccharides / chemistry*
Polysaccharides / pharmacology*
Spectroscopy, Fourier Transform Infrared
|
| IF |
5.162
|
| Times Cited |
11
|
|
WOS Category
|
POLYMER SCIENCE
BIOCHEMISTRY & MOLECULAR BIOLOGY
CHEMISTRY, APPLIED
|
| Resource |
| Human and Animal Cells |
MCF7(RCB1904) |
