RRC ID |
36916
|
著者 |
Wada S, Kubota Y, Sawa R, Umekita M, Hatano M, Ohba S, Hayashi C, Igarashi M, Nomoto A.
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タイトル |
Novel autophagy inducers lentztrehaloses A, B and C.
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ジャーナル |
J Antibiot (Tokyo)
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Abstract |
Trehalose has widespread use as a sweetener, humectant and stabilizer, and is now attracting attention as a promising candidate for the treatment of neurodegenerative diseases as it is an autophagy inducer and chemical chaperone. However, the bioavailability of trehalose is low because it is digested by the hydrolyzing enzyme trehalase, expressed in the intestine and kidney. Enzyme-stable analogs of trehalose would potentially solve this problem. We have previously reported an enzyme-stable analog of trehalose, lentztrehalose, and herein report two new analogs. The original lentztrehalose has been renamed lentztrehalose A and the analogs named lentztrehaloses B and C. Lentztrehalose B is a di-dehydroxylated analog and lentztrehalose C is a cyclized analog of lentztrehalose A. All the lentztrehaloses are only minimally hydrolyzed by mammalian trehalase. The production of the lentztrehaloses is high in rather dry conditions and low in wet conditions. Lentztrehalose B shows a moderate antioxidative activity. These facts suggest that the lentztrehaloses are produced as humectants or protectants for the producer microorganism under severe environmental conditions. All the lentztrehaloses induce autophagy in human cancer cells at a comparable level to trehalose. Considering the enzyme-stability, these lentztrehaloses can be regarded as promising new drug candidates for the treatment of neurodegenerative diseases and other autophagy-related diseases, such as diabetes, arteriosclerosis, cancer and heart disease.
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巻・号 |
68(8)
|
ページ |
521-9
|
公開日 |
2015-8-1
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DOI |
10.1038/ja.2015.23
|
PII |
ja201523
|
PMID |
25757606
|
PMC |
PMC4579591
|
MeSH |
Autophagy / drug effects*
Cell Line, Tumor
Cell Survival / drug effects
Drug Stability
Humans
Hydrolysis
Molecular Structure
Trehalase / metabolism
Trehalose / analogs & derivatives*
Trehalose / chemistry
Trehalose / isolation & purification
Trehalose / metabolism
|
IF |
2.668
|
引用数 |
8
|
WOS 分野
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
MICROBIOLOGY
IMMUNOLOGY
|
リソース情報 |
ヒト・動物細胞 |
OVK18(RCB1903) |