Reference - Detail
| RRC ID | 36917 |
|---|---|
| Author | Siddiqi MZ, Siddiqi MH, Kim YJ, Jin Y, Huq MA, Yang DC. |
| Title | Effect of Fermented Red Ginseng Extract Enriched in Ginsenoside Rg3 on the Differentiation and Mineralization of Preosteoblastic MC3T3-E1 Cells. |
| Journal | J Med Food |
| Abstract |
In this study, red ginseng extract (RGE) was converted into high-content minor ginsenosides by fermenting with Bgp1 enzymes at 37°C for 5 days. Compared to the RGE, the minor ginsenoside contents were increased in fermented red ginseng extract (FRGE). Moreover, the amount of minor ginsenosides such as Rh1 (11%) and Rg2 (16%) was slightly augmented, while the level of Rg3 (33%) was significantly increased after bioconversion. Furthermore, we also examined and compared the effect of RGE and FRGE on the differentiation and mineralization of preosteoblastic MC3T3-E1 cells. Similarly, the level of mRNA expression of intracellular alkaline phosphatase (ALP) activity, type-1 collagen (Col-I) was also increased. Based on the comparison, it is clear that the FRGE has improved effects on bone formation and differentiation of preosteoblastic MC3T3-E1 cells. |
| Volume | 18(5) |
| Pages | 542-8 |
| Published | 2015-5-1 |
| DOI | 10.1089/jmf.2014.3251 |
| PMID | 25764149 |
| PMC | PMC4410546 |
| MeSH | Alkaline Phosphatase / metabolism Animals Calcification, Physiologic / drug effects Cell Differentiation / drug effects* Cell Proliferation / drug effects Collagen Type I / metabolism Ginsenosides / pharmacology* Mice Osteoblasts / cytology Osteoblasts / drug effects* Osteoblasts / metabolism Panax / chemistry* Plant Extracts / pharmacology* |
| IF | 2.04 |
| Times Cited | 19 |
| WOS Category | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, MEDICINAL NUTRITION & DIETETICS |
| Resource | |
| Human and Animal Cells | MC3T3-E1(RCB1126) |