論文 - 詳細
| RRC ID | 37006 |
|---|---|
| 著者 | Ogawa-Ohnishi M, Matsushita W, Matsubayashi Y. |
| タイトル | Identification of three hydroxyproline O-arabinosyltransferases in Arabidopsis thaliana. |
| ジャーナル | Nat Chem Biol |
| Abstract |
Hydroxyproline (Hyp) O-arabinosylation is a post-translational modification that is prominent in extracellular glycoproteins in plants. Hyp O-arabinosylation is generally found in these glycoproteins in the form of linear oligoarabinoside chains and has a key role in their function by contributing to conformational stability. However, Hyp O-arabinosyltransferase (HPAT), a key enzyme that catalyzes the transfer of the L-arabinose to the hydroxyl group of Hyp residues, has remained undiscovered. Here, we purified and identified Arabidopsis HPAT as a Golgi-localized transmembrane protein that is structurally similar to the glycosyltransferase GT8 family. Loss-of-function mutations in HPAT-encoding genes cause pleiotropic phenotypes that include enhanced hypocotyl elongation, defects in cell wall thickening, early flowering, early senescence and impaired pollen tube growth. Our results indicate essential roles of Hyp O-arabinosylation in both vegetative and reproductive growth in plants. |
| 巻・号 | 9(11) |
| ページ | 726-30 |
| 公開日 | 2013-11-1 |
| DOI | 10.1038/nchembio.1351 |
| PII | nchembio.1351 |
| PMID | 24036508 |
| MeSH | Arabidopsis / enzymology* Hydroxyproline / metabolism* Molecular Conformation Pentosyltransferases / analysis* Pentosyltransferases / metabolism* |
| IF | 12.587 |
| 引用数 | 76 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| シロイヌナズナ / 植物培養細胞・遺伝子 | rpc00008 |