| RRC ID |
37038
|
| 著者 |
Gümüşderelioğlu M, Tunçay EÖ, Kaynak G, Demirtaş TT, Aydın ST, Hakkı SS.
|
| タイトル |
Encapsulated boron as an osteoinductive agent for bone scaffolds.
|
| ジャーナル |
J Trace Elem Med Biol
|
| Abstract |
The aim of this study was to develop boron (B)-releasing polymeric scaffold to promote regeneration of bone tissue. Boric acid-doped chitosan nanoparticles with a diameter of approx. 175 nm were produced by tripolyphosphate (TPP)-initiated ionic gelation process. The nanoparticles strongly attached via electrostatic interactions into chitosan scaffolds produced by freeze-drying with approx. 100 μm pore diameter. According to the ICP-OES results, following first 5h initial burst release, fast release of B from scaffolds was observed for 24h incubation period in conditioned medium. Then, slow release of B was performed over 120 h. The results of the cell culture studies proved that the encapsulated boron within the scaffolds can be used as an osteoinductive agent by showing its positive effects on the proliferation and differentiation of MC3T3-E1 preosteoblastic cells.
|
| 巻・号 |
31
|
| ページ |
120-8
|
| 公開日 |
2015-1-1
|
| DOI |
10.1016/j.jtemb.2015.03.008
|
| PII |
S0946-672X(15)00038-3
|
| PMID |
26004902
|
| MeSH |
Adsorption
Animals
Biomarkers / metabolism
Bone Density Conservation Agents / administration & dosage
Bone Density Conservation Agents / chemistry*
Bone Density Conservation Agents / pharmacology
Bone Regeneration / drug effects
Boric Acids / administration & dosage
Boric Acids / chemistry
Boric Acids / pharmacology
Boron / administration & dosage
Boron / chemistry*
Boron / pharmacology
Cell Line
Cell Proliferation / drug effects
Chitosan / chemistry
Delayed-Action Preparations / administration & dosage
Delayed-Action Preparations / chemistry
Delayed-Action Preparations / pharmacology
Drug Compounding
Drug Delivery Systems*
Drug Liberation
Mice
Microscopy, Electron, Scanning
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Osteoblasts / cytology
Osteoblasts / drug effects*
Osteoblasts / ultrastructure
Osteogenesis / drug effects*
Particle Size
Porosity
Tissue Scaffolds / chemistry*
|
| IF |
3.245
|
| 引用数 |
23
|
|
WOS 分野
|
ENDOCRINOLOGY & METABOLISM
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
