RRC ID 37077
Author Yamashita-Kanemaru Y, Takahashi Y, Wang Y, Tahara-Hanaoka S, Honda S, Bernhardt G, Shibuya A, Shibuya K.
Title CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation.
Journal J. Immunol.
Abstract Although Th1 and Th2 cells are known to be involved in allergic inflammatory diseases, the molecular mechanisms underlying their differentiation are incompletely understood. In this study, we identified CD155 as a costimulatory molecule on CD4(+) T cells. Importantly, CD155-mediated signaling induced Th1 development in both humans and mice, as evidenced by production of IFN-γ and upregulation of Tbx21 transcription; these effects were independent of IL-12 but dependent on NF-κB-induced autocrine IFN-γ that triggered positive feedback via STAT1 activation. Mice genetically deficient in CD155 or treated with anti-CD155 Ab exhibited attenuated Th1-type contact hypersensitivity. Thus, CD155 plays an important regulatory role in helper T cell differentiation and allergic diseases.
Volume 194(12)
Pages 5644-53
Published 2015-6-15
DOI 10.4049/jimmunol.1401942
PII jimmunol.1401942
PMID 25972481
MeSH Animals Antibodies, Monoclonal / administration & dosage Antibodies, Monoclonal / pharmacology CD4-Positive T-Lymphocytes / immunology* CD4-Positive T-Lymphocytes / metabolism* Dermatitis, Contact / drug therapy Dermatitis, Contact / immunology Dermatitis, Contact / metabolism Disease Models, Animal Humans Hypersensitivity / drug therapy Hypersensitivity / immunology* Hypersensitivity / metabolism* Interferon-gamma / metabolism Interleukin-12 / metabolism Mice Mice, Knockout Phosphorylation Receptors, Virus / antagonists & inhibitors Receptors, Virus / genetics Receptors, Virus / metabolism* Signal Transduction* Th1 Cells / immunology Th1 Cells / metabolism
IF 4.539
Times Cited 3
Human and Animal Cells