RRC ID 37331
Author Mori IC, Arias-Barreiro CR, Koutsaftis A, Ogo A, Kawano T, Yoshizuka K, Inayat-Hussain SH, Aoyama I.
Title Toxicity of tetramethylammonium hydroxide to aquatic organisms and its synergistic action with potassium iodide.
Journal Chemosphere
Abstract The aquatic ecotoxicity of chemicals involved in the manufacturing process of thin film transistor liquid crystal displays was assessed with a battery of four selected acute toxicity bioassays. We focused on tetramethylammonium hydroxide (TMAH, CAS No. 75-59-2), a widely utilized etchant. The toxicity of TMAH was low when tested in the 72 h-algal growth inhibition test (Pseudokirchneriellia subcapitata, EC50=360 mg L(-1)) and the Microtox® test (Vibrio fischeri, IC50=6.4 g L(-1)). In contrast, the 24h-microcrustacean immobilization and the 96 h-fish mortality tests showed relatively higher toxicity (Daphnia magna, EC50=32 mg L(-1) and Oryzias latipes, LC50=154 mg L(-1)). Isobologram and mixture toxicity index analyses revealed apparent synergism of the mixture of TMAH and potassium iodide when examined with the D. magna immobilization test. The synergistic action was unique to iodide over other halide salts i.e. fluoride, chloride and bromide. Quaternary ammonium ions with longer alkyl chains such as tetraethylammonium and tetrabutylammonium were more toxic than TMAH in the D. magna immobilization test.
Volume 120
Pages 299-304
Published 2015-2-1
DOI 10.1016/j.chemosphere.2014.07.011
PII S0045-6535(14)00861-3
PMID 25151133
MeSH Aliivibrio fischeri / drug effects Animals Aquatic Organisms / drug effects* Chlorophyta / drug effects Daphnia / drug effects Drug Synergism Oryzias / metabolism Potassium Iodide / toxicity* Quaternary Ammonium Compounds / toxicity* Water Pollutants, Chemical / toxicity*
IF 5.778
Times Cited 26
Algae NIES-35