論文 - 詳細
| RRC ID | 37474 |
|---|---|
| 著者 | Hanschen ER, Marriage TN, Ferris PJ, Hamaji T, Toyoda A, Fujiyama A, Neme R, Noguchi H, Minakuchi Y, Suzuki M, Kawai-Toyooka H, Smith DR, Sparks H, Anderson J, Bakarić R, Luria V, Karger A, Kirschner MW, Durand PM, Michod RE, Nozaki H, Olson BJ. |
| タイトル | The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity. |
| ジャーナル | Nat Commun |
| Abstract |
The transition to multicellularity has occurred numerous times in all domains of life, yet its initial steps are poorly understood. The volvocine green algae are a tractable system for understanding the genetic basis of multicellularity including the initial formation of cooperative cell groups. Here we report the genome sequence of the undifferentiated colonial alga, Gonium pectorale, where group formation evolved by co-option of the retinoblastoma cell cycle regulatory pathway. Significantly, expression of the Gonium retinoblastoma cell cycle regulator in unicellular Chlamydomonas causes it to become colonial. The presence of these changes in undifferentiated Gonium indicates extensive group-level adaptation during the initial step in the evolution of multicellularity. These results emphasize an early and formative step in the evolution of multicellularity, the evolution of cell cycle regulation, one that may shed light on the evolutionary history of other multicellular innovations and evolutionary transitions. |
| 巻・号 | 7 |
| ページ | 11370 |
| 公開日 | 2016-4-22 |
| DOI | 10.1038/ncomms11370 |
| PII | ncomms11370 |
| PMID | 27102219 |
| PMC | PMC4844696 |
| MeSH | Biological Evolution Cell Cycle Checkpoints / genetics* Chlamydomonas / cytology Chlamydomonas / genetics* Chlorophyta / classification Chlorophyta / cytology Chlorophyta / genetics* Gene Expression Regulation, Plant* Genome Size Genome, Plant* Phylogeny Plant Cells / metabolism Plasmids / chemistry Plasmids / metabolism Retinoblastoma Protein / genetics Retinoblastoma Protein / metabolism Transformation, Genetic |
| IF | 12.121 |
| 引用数 | 63 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 132 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 藻類 | NIES-2016 |